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Certainly not, provided it has taken effect in more than one place. The arm is frequently much inflamed, and vaccinating other children from it abates the inflammation, and thus affords relief. It is always well to leave one vesicle undisturbed. If the infant have any "breaking out" upon the skin, ought that to be a reason for deferring the vaccination?

But it does please me to read the first descriptions of parts to which the names of their discoverers or those who have first described them have become so joined that not even modern science can part them; to listen to the talk of my old volume as Willis describes his circle and Fallopius his aqueduct and Varolius his bridge and Eustachius his tube and Monro his foramen, all so well known to us in the human body; it does please me to know the very words in which Winslow described the opening which bears his name, and Glisson his capsule and De Graaf his vesicle; I am not content until I know in what language Harvey announced his discovery of the circulation, and how Spigelius made the liver his perpetual memorial, and Malpighi found a monument more enduring than brass in the corpuscles of the spleen and the kidney.

By the aid of the microscope we find that these ova are composed of granular substance, in which is found a miniature yolk surrounded by a transparent membrane called the zona pellucida. This yolk contains a germinal vesicle in which can be discovered a nucleus, called the germinal spot.

But, with one or two individual exceptions, as plants and animals evolve, the union of two elements, male and female, is needed to start the amazingly complex process of building a new individual. Thus in flowers the stamens, the pollen bearers, provide the male element which, through the intermediary of the pistils, fertilizes the egg in the vesicle.

But when "grey-matter" that composes this thinking mechanism becomes diseased, and the cold touch of death stills the action of fibre and vesicle, what light can our teachers pour upon the future of that coagulated substance where once reigned hope, ambition, love, or hate? Those grey granules that were memory, become oblivion. Certainly physiology has grown to giant stature since the days of St.

The disease went through its course without any deviation from its usual habits; and, notwithstanding this, the cow-pox virus excited its common appearances, both on the arm and on the constitution, without any febrile interruption; on the sixth day there was a vesicle. 8th: Pain in the axilla, chilly, and affected with headache. 9th: Nearly well.

I know a gentleman who, many years ago, was inoculated for the smallpox, but having no pustules, or scarcely any constitutional affection that was perceptible, he was dissatisfied, and has since been repeatedly inoculated. A vesicle has always been produced in the arm in consequence, with axillary swelling and a slight indisposition; this is by no means a rare occurrence.

This resemblance is so close in the main features that we have only to repeat what we have already said of the ontogenesis of the Amphioxus. In the thick fine-grained yelk we find a clear round germinal vesicle of about 1/750 of an inch in diameter, and this encloses a small embryonic spot or nucleolus.

And now we have a perfect cell-structure, differing from an ordinary cell only in having the inner sac, inclosing the dot, on the side, instead of in the centre. The outer membrane corresponds to the Ectoblast, or outer cell sac, the Purkinjean vesicle to the Mesoblast, or inner cell sac, while the dot in the centre answers to the Entoblast.

We must, however, bear in mind that this violent disease does not always appear in the same form, and that while the essence of the poison which it produces, and which is separated so abundantly from the body of the patient, remains unchanged, it is proteiform in its varieties, from the almost imperceptible vesicle, unaccompanied by fever, which exists for some time before it extends its poison inwardly, and then excites fever and buboes, to the fatal form in which carbuncular inflammations fall upon the most important viscera.