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Updated: June 13, 2025
"Pilocarpin, of course!" What luck! He fervently blessed the shortage of phenacetin that had forced him to take pilocarpin as a sweating substitute for fever. "Cazi Moto!" he called. Then, as the headman hurried up: "Get me the box of medicines, quick!" He waited until he heard the little man reenter the tent. "Place it here," he commanded. "Now go." He groped for the case, opened it
Prentiss of Washington, D.C., in 1881 reported a remarkable case of pilocarpin idiosyncrasy in a blonde of twenty-five. He was consulted by the patient for constipation. Later on symptoms of cystitis developed, and an ultimate diagnosis of pyelitis of the right kidney was made. Uremic symptoms were avoided by the constant use of pilocarpin.
There is a good deal of clinical evidence to indicate that in this type of glaucoma, as well as in the so-called sub-acute varieties, myotic activity is increased by a mixture of pilocarpin and eserin in the same solution, exactly as a mixture of arecalin and eserin is more potent than either of the drugs in separate solution.
Then he spoke to Cazi Moto in a vibrating voice. "Bring me the chest of medicines. Now," he went on to Winkleman, when this command had been executed, "kindly read to me the labels on all these bottles; begin at the left. All, please." He listened attentively while Winkleman obeyed. The pilocarpin was present; the atropin was gone. "You have not deceived me?" he cried sharply.
Pilocarpin, and salicylate of soda, and mercury do not tend towards cheerfulness. Nor do blisters on the forehead add to the content of life! 'I quite understand, said Stephen, 'and I will be careful not to go near him till he is well. Please God! it may bring him back his sight. Thank you a thousand times for your determination to stay with him.
But while he contemplated this mental image, it shifted. The pilocarpin and atropin changed places. And this latter recollection seemed as distinct to him as the first had been. He fingered the three bottles, his brows bent. And across his mental travail floated another thought that brought him up all standing. Pilocarpin and atropin had exactly the opposite effect.
At the same end of the case were the receptacles also of the atropin and the morphia. He remembered the Leopard Woman's remarking how much alike they all were. Kingozi seemed to see plainly in his mind's eye the precise arrangement, to visualize even the exact appearance of the labels on the bottles first the morphia, next to it the pilocarpin, and last the atropin.
Kingozi sat quietly, turning his head to either side, raising or lowering his chin as he was requested to do so. At last McCloud straightened his back. "It is glaucoma right enough," said he; "fairly advanced. The pilocarpin has been a palliative. An operation is called for iridectomy." He paused, wiping his mirror. Nobody dared ask the question that Kingozi himself at last propounded.
One makes a transverse incision above the cornea " "I know, I know," interrupted Kingozi. "But the pilocarpin will give me my sight. Let us get at it." Three hours later Kingozi stepped into the open, his vision cleared. Such is often the marvellous though temporary effect of the proper remedies in this disease.
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