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Updated: June 5, 2025
Before proceeding to inquire further into this particular case, let us here and now say that, just as to-day there is no inorganic toxin known to science that will either lie fallow for weeks in the human system, suddenly to become active and slay, or yet to kill by slow degrees involving some weeks in the process, so none was known in the Borgian or any other era.
The specific germ of the disease, or the toxin elaborated by this germ, may be especially depressant to the heart, as in diphtheria, or the germ may be particularly prone to locate in the heart, as in rheumatism and pneumonia. But all feverish processes, sooner or later, if sufficiently prolonged, cause serious cardiac weakness and more or less dilatation.
S. Weir Mitchell's figures indicate 8.7 per cent. mortality for rattlesnake bite. This would make the venom about as dangerous as the toxin of typhoid fever, which is not generally regarded as a necessarily "deadly" disease. Other writers go as high as fifteen per cent. for the rattlesnake and as low as one per cent. for the copperhead.
It was the pure toxin, placed in his glass before the wine was poured." Once more the unfortunate director's death was reproduced before us. "Struck down," exclaimed Craig, "as though by some invisible lightning bolt, without mercy, without a chance, without the slightest bit of compunction! Why? I'll tell you. Because he suspected, in fact knew, who the guilty person was.
The flying pieces of glass injected the poison as by a myriad of hypodermic needles the highly poisonous toxin of abrin, product of the jequirity, which is ordinarily destroyed in the stomach but acts powerfully if injected into the blood. Shirley died of jequirity poisoning, or rather of the alkaloid in the bean. It has been used in India for criminal poisoning for ages.
When he became capable of ordinary occurrences she detailed all that had happened, and said that he alone was to blame for the sad bereavement. He replied: "The toxin generates the anti-toxin. The end lies concealed in the beginning. All bodies grow around a skeleton. Life is a petticoat about death. I will not go to bed."
As the toxin spreads it causes both motor hyper-tonus and hyper-excitability, which accounts for the tonic contraction and the clonic spasms characteristic of tetanus. [Illustration: FIG.
To conclude, then: the inheritance of an acquired peculiarity in the experiments of Brown-Séquard can be explained by the effect of a toxin on the germ. The lesion, however well localized it seems, is transmitted by the same process as, for instance, the taint of alcoholism. But may it not be the same in the case of every acquired peculiarity that has become hereditary?
The separation of the slough is a tedious process, and the patient may become exhausted by pain, discharge, and toxin absorption. When the slough is finally thrown off, a deep gap is left, which takes a long time to heal.
I can prove that the nurse had access to the laboratory; it would be easy to make a jury believe that she put the toxin in the syringe herself, with the insane idea of making trouble for me. If she's not to be found, I should not have much difficulty in getting away with that theory. But it will never come to that." "You seem devilish sure, but all the same "
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