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Updated: May 5, 2025
The dog was being kept alive, although perhaps a third of his blood was out of his body. "You see," he said at length, after we had watched the process a few minutes, "what I have here is in reality an artificial kidney. It is a system that has been devised by several doctors at Johns Hopkins. "If there is any toxin in the blood of this dog, the kidneys are naturally endeavoring to eliminate it.
It followed without hesitation, distinct and clear: "But certainly, mademoiselle, I can tell you. The needle contained, tout simplement, what one calls in English the pure toxin of typhoid!" "Toxin of typh...." The words died in her throat, the receiver dropped clattering down. For an instant she sat as though paralysed, her dry lips parted, her eyes staring in front of her.
The murderess chooses the under part of the chin as the point attacked in order to strike the principal nerve-centres, the cephalic ganglia, and thus to do away with life at one blow. When this vital seat is poisoned by the toxin, death is instantaneous.
None who seeks to enter the Kingdom will ever be hindered by this devout disciple of truth in whose blood is no drop of the toxin of Pharisaism. You may see the intellectual charity of the man in his attitude towards other teachers of our time whose views are opposed to his own.
Bardeen suggests that these morbid phenomena correspond so closely to those met with where the presence of a toxin is known to produce them, that in all probability death is similarly due to the action of some poison produced by the action of heat on the skin and on the proteins of the blood.
"Indeed, it is surprising," he resumed thoughtfully, "how many an innocent substance can be changed by bacteria into a virulent poison. In fact our poisons and our drugs are in many instances the close relations of harmless compounds that represent the intermediate steps in the daily process of metabolism." "Then," I put in, "the toxin was produced by germs, after all?"
For instance, nearly two-thirds of our diphtheria cases, which are properly examined, will show albumin in the urine, showing that the kidney-cells have been attacked and poisoned by the toxin. This may go on to a fatal attack of uremia; but fortunately, not commonly, far less so than in scarlet fever. The kidneys usually recover completely, but this may take weeks and months.
They were stealing their ghostly, paralyzing way low down upon the ground, drifting heavily along until the open below brought them to the stronger air currents which would disperse them on their eastward journey, robbing them of their deadly toxin, and reducing them to a simple sickly perfume. He had leapt to his feet.
Finally he held up a test tube and turned to us. "What is it?" I asked. "Some other poison as rare and little known as the snake venom?" "No something much more curious. In the stem of the glass I find the toxin of the Bacillus botulinus." "Germs?" Mackay inquired. Kennedy shook his head. "Not germs, but the pure toxin, the poison secreted by this bacillus." "What does it do?" was my question.
Instantly attention was turned in this direction, and it was quickly found that if a guinea-pig were injected with a very small dose of the diphtheria toxin and allowed to recover, he would then be able to throw off a still larger dose, until finally, after a number of weeks, he could be given a dose which would have promptly killed him in the beginning of the experiments, but which he now readily resisted and recovered from.
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