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Sclerosis of the meshwork of the iris angle is the predisposing factor because it hinders free access of aqueous into the venous sinus of Schlemm. Sclerosis alone, however, will not cause glaucoma so long as access to the iris veins can keep the intra-ocular pressure at the intra-venous level, and, too, as long as the exciting cause is absent.
The word had gone round that I was a Freeman, and I was forced to join the local lodge, same as you did last night. I've the badge of shame on my forearm and something worse branded on my heart. I found that I was under the orders of a black villain and caught in a meshwork of crime. What could I do? Every word I said to make things better was taken as treason, same as it was last night.
Not a boat of any kind was at present within sight, but far in the distance Budmouth lay upon the sea, as it were quietly regarding his efforts, and beside the town the harbour showed its position by a dim meshwork of ropes and spars.
But, among the countless numbers of those characters so strangely mixed among us, in which the dark and the bright fibres cross like a meshwork; characters at one moment capable of acts of heroic greatness, at another hurried by temptation into actions which even common men may deplore, how many are there who have never availed themselves of the conditions of reconciliation as orthodoxy proffers them, and of such men what is to be said?
The great unsuspicious birds were very near now, so near that a white hunter would have lost his equanimity in anticipation. Through the meshwork of the blind the stalker counted them. Twenty-seven there were together, and near to him another, a sentinel.
There is no endothelial lining, and the fibrous tissue of the wall is in immediate contact with the colloid material in the interior, which appears to be derived by a process of degeneration from the surrounding connective tissue. In the region of the knee the ganglion is usually multilocular, and consists of a meshwork of fibrous tissue, the meshes of which are occupied by colloid material.
He climbed mechanically upwards, digging his toes into the meshwork of the sides, and sobbing from sheer weakness as he climbed. He made a small parting in the roof, and peeped out. It was only for a moment, for he fell back stunned and blinded by the glare. Still, in that moment, he had caught a glimpse of an unfamiliar world, leafless, lifeless, silent, miserable.
To summarize: The aqueous has direct access to the anterior uveal venous system; the physiological thickening of the strands of the meshwork of the iris angle supplies a mechanical obstruction between the anterior chamber and the venous sinus of Schlemm; intra-ocular pressure stands at the same level as the intra-venous, consequently, the hydrostatic pressure is the same on both sides of the iris angle meshwork, because the canal of Schlemm is a secondary venous system; lastly, the outflow of aqueous into the venous sinus is by diffusion, not by filtration, because the pressure is the same on both sides of the meshwork.
When these two factors coexist in their varying combinations, pathological increase of pressure results in short, glaucoma. Syphilis, rheumatism, gout, auto-intoxication and many other constitutional disorders are well recognized agencies which induce sclerosis in body tissues, so there can be little doubt that these conditions produce pathological sclerosis of the meshwork of the iris angle.
Placed together, they make a net laid in advance, a strong meshwork in which the human intelligence posts itself securely to spy the flux of reality, and seize it as it passes. Such a proceeding is made for the practical world, and is out of place in the speculative.
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