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Now, this change is undoubtedly accompanied by phenomena of organic destruction: to these, and to these alone, will a mechanistic explanation of ageing be confined. It will note the facts of sclerosis, the gradual accumulation of residual substances, the growing hypertrophy of the protoplasm of the cell. But under these visible effects an inner cause lies hidden.
When these two factors coexist in their varying combinations, pathological increase of pressure results in short, glaucoma. Syphilis, rheumatism, gout, auto-intoxication and many other constitutional disorders are well recognized agencies which induce sclerosis in body tissues, so there can be little doubt that these conditions produce pathological sclerosis of the meshwork of the iris angle.
Small doses of iodid, however, when indicated in various kinds of sclerosis, have seemed to lower blood pressure. While large doses may have more of this actioli, they are not now under consideration, and large doses are rarely indicated. Too mach iodid has been given for many conditions.
"Stupid as it may seem, I didn't," admitted Cochrane. "I haven't the least idea what you're talking about." Jones looked at him patiently. "Now we can shoot our exhaust out of the field! The ship-field, not the main one!" "I'm still numb," said Cochrane. "Multiple sclerosis of the brain-cells, I suppose. Let me just take your word for it." Jones tried once more. "Try to see it! Listen!
On the other hand, if Fischer believes that sclerosis of the meshwork of the iris angle is a result and not a cause of glaucoma, then it would seem that Henderson has the better of the argument. The physiological changes in this structure, which take place with advancing age, can rightfully be looked upon as a predisposing factor in glaucoma. Dr.
In my tests here to-day, I injected four one-hundredths of a grain of indol into a guinea-pig. The animal had sclerosis or hardening of the aorta. The liver, kidneys, and supra-renals were affected, and there was a hardening of the brain. In short, there were all the symptoms of old age." We sat aghast. Indol! What black magic was this? Who put it in the food?
It amounted to an effort to make your mental sclerosis infectious, and it was all the worse because, in you, the stiffening of the tastes had taken the form of aversions rather than preferences. You did not so much wish your readers to like your favorite authors as to hate all the others.
In cases of long continued increase of tension minute permanent vesicles form in the epithelial layers, particularly in the superficial portion. In advanced cases of glaucoma after the congestive period has subsided the cornea becomes somewhat condensed, the lymph spaces contracted; a condition of sclerosis obtains. Alteration in the shape of the cornea occurs only rarely in adult life.
Less frequently the trabecular framework is added to by the formation of new bone, resulting in a remarkable degree of sclerosis, and if, following upon this, there is caseation of the tubercle and death of the affected portion of bone, there results a sequestrum often of considerable size and characteristic shape, which, because of the sclerosis and surrounding endarteritis, is exceedingly slow in separating.
If the indications for an iodid are present, such as sclerosis anywhere, or unabsorbed inflammatory products, exudation in or around the heart, or an apparent insufficiency of the thyroid, from 0.1 to 0.2 gm. It is sometimes a question whether small doses of iodid are not actually stimulant to the heart, possibly through the action on the thyroid gland.
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