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Updated: May 14, 2025
In my tests here to-day, I injected four one-hundredths of a grain of indol into a guinea-pig. The animal had sclerosis or hardening of the aorta. The liver, kidneys, and supra-renals were affected, and there was a hardening of the brain. In short, there were all the symptoms of old age." We sat aghast. Indol! What black magic was this? Who put it in the food?
"The ring or contact test for indol," Kennedy replied, with evident satisfaction. "When the acid and the nitrites are mixed the colour reaction is unsatisfactory. The natural yellow tint masks that pink tint, or sometimes causes it to disappear, if the tube is shaken. But this is simple, clear, delicate unescapable. There was indol in that food of yours, Mr. Pitts." "Indol?" repeated Pitts.
"Is," explained Kennedy, "a chemical compound one of the toxins secreted by intestinal bacteria and responsible for many of the symptoms of senility. It used to be thought that large doses of indol might be consumed with little or no effect on normal man, but now we know that headache, insomnia, confusion, irritability, decreased activity of the cells, and intoxication are possible from it.
Pitts, and, to escape detection, killed your faithful chef and covered his own traces so cleverly?" rapped out Kennedy. "Who would have known the new process of healing wounds? Who knew about the fatal properties of indol? Who was willing to forego a one-hundred-thousand-dollar prize in order to gain a fortune of many hundreds of thousands?"
We have studied the brain-cells in human cases of fever, and in animals after prolonged insomnia; after the injection of the toxins of gonococci, of streptococci, of staphylococci, and of colon, tetanus, diphtheria, and typhoid bacilli; and after the injection of foreign proteins, of indol and skatol, of leucin, and of peptones.
Comparatively small doses over a long time produce changes in organs that lead to serious results. "It is," went on Kennedy, as the full horror of the thing sank into our minds, "the indol-and phenol-producing bacteria which are the undesirable citizens of the body, while the lactic-acid producing germs check the production of indol and phenol.
We have recorded 66 clear-cut experiments on dogs, which show that after fear and rage, after anaphylaxis, after injections of indol and skatol, of leucin and creatin, of the toxins of diphtheria and colon bacilli, of streptococci and staphylococci, of foreign proteins, and of strychnin, the Cannon test for adrenalin was positive.
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