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Locomotor ataxia and softening of the brain, early apoplexy, blindness and deafness, paralysis, chronic fatal kidney and liver disease, heart failure, hardening of the blood-vessels early in life, with sudden or lingering death from any of these causes, are among the ways in which syphilis destroys innocent and guilty alike.

Now, if certain parts of the brain are made to blush or turn pale, there is no doubt that hypnotism will follow, since blushing and turning pale are known to be due to the opening and closing of the blood-vessels. We may say that the subject is induced by some means to shut the blood out of certain portions of the brain, and keep it out until he is told to let it in again.

On the other hand, if the brain remains vigorous, the kidneys may take the strain and break down; if the kidneys do not break, the blood-vessels may harden; if the blood-vessels are not affected, the thyroid may become hyperplastic and produce Graves' disease; if the thyroid escapes, diabetes may develop; while if the iron constitution of the mechanism can successfully bear the strain in all its parts, then the individual will break his competitors, and their mechanisms will suffer in the struggle.

The increased action of the muscles of the heart and the blood-vessels increases the efficiency of the circulation; the secretion of the adrenal gland causes a rise in the blood-pressure; the increased action of the thyroid gland causes an increased metabolic activity; there is evidence that glycogen is actively called out, this being the most immediately available substance for the production of energy; the increased activity of the respiration is needed to supply the greater need of oxygen and the elimination of the increased amount of waste products; the dilatation of the nostrils affords a freer intake of air; the increased activity of the sweat-glands is needed to regulate the temperature of the body which the increased metabolism causes to rise.

Their origin was to be looked for in the progressive removal of the customary atmospheric pressure upon the surface of the body, and consequent distention of the superficial blood-vessels not in any positive disorganization of the animal system, as in the case of difficulty in breathing, where the atmospheric density is chemically insufficient for the due renovation of blood in a ventricle of the heart.

Motley's case was a striking illustration that the renal disease of so-called Bright's disease may supervene as part and parcel of a larger and antecedent change in the blood-vessels in other parts than the kidney. . . . I am, my dear sir, Yours very truly, WILLIAM W. GULL. To OLIVER WENDELL HOLMES, ESQ. I first saw Mr.

Of the latter it cannot reasonably be supposed that the ova ever pass through the medium of the air, or through the blood-vessels, for they are too heavy for the one transit, and too large for the other.

In severe cases, the blood-vessels around the margin of the cornea become prominent, and ulcers form on its surface. The animal's appetite is impaired or lost. There is loss of flesh and temporary blindness. The blindness in one or both eyes may persist for a period of from two weeks to several months. Permanent blindness is comparatively rare.

Though their disturbances give rise to visions of all sorts there is nothing visionary about them; they are just as genuine and substantial a part of our bodily structure as our bones, muscles, and blood-vessels. In fact, it was this very substantiality that at the beginning prevented their proper recognition, and handicapped them with their present absurd and inappropriate name.

The peritoneum seemed to be dyed from its immersion in this fluid, as it showed a general red hue, not apparently deeper in some parts than in others. There was an absence, to a great extent, of that beautiful appearance and well-marked course of the minute blood-vessels which accompany many cases of original peritonitis.

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