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Updated: July 26, 2025


These unadapted adrenals, as we may call them, once sowed the seeds, expending their masculinism in the struggles of the pioneers' martyrdoms, preparing the harvest their sisters, the more adequate adrenal types, will now reap. The unadapted adrenals of today will have to look for new worlds to conquer. So much for the compensated adrenal types.

One such has been named the kinetic system because it comes into play in situations which demand prompt adaptation without hesitancy, and a consequent immediate transformation of static or stored energy into kinetic or active energy. According to this conception the brain, the adrenals, the liver, the thyroid and the muscles together constitute a machine very much like an automobile.

And so thousands with dangerously unstable adrenals were plunged into the most trying conditions possible. Hundreds of them, already shaken, on the borderland of instability, reacted with the phenomena of breakdown of control, lumped with a host of other phenomena, under the general rubric of "shell shock." That alone was not all. If hundreds collapsed, thousands approached the verge of collapse.

In particular, this applies to the sugar mechanism in the liver under the discipline of the check and drive organization. The adrenal and the pancreas are the direct antagonists in the struggle for control of sugar. Removal of the adrenals will cause a decrease in the amount of sugar in the blood, while removal of the pancreas will produce an increase.

A positive answer may be given to this question, for the evidence of the dependence of the brain upon the adrenals is as clear as is the evidence of the dependence of the adrenals upon the brain. After excision of the adrenals, the brain-cells undergo continuous histologic and functional deterioration until death.

Concomitantly, there is a changed, a more matured and steadier outlook upon life, all due to stimulation of the anterior pituitary, controller of growth, physical and mental. In general, the major endocrines, the pituitary, the adrenals, and the thyroid should hypertrophy and hyperfunction during pregnancy.

So the tonsillitis, which in another type of individual would have been combatted continuously by the adrenals and so passed by as a mere sore throat, presented him with a high temperature, and the brain disturbance described by the medical officer as exhaustion-psychosis, with again a tendency to violence.

Albans he would ride for three hours at the end of the day to tire himself sufficiently for sleep. That his adrenals were not affected is indicated by the brutality which remained characteristic to the end of his life. The findings after death confirm the view of him as an unstable pituitocentric who succumbed to pituitary insufficiency toward the latter half of his life.

He was not a good animal, as Herbert Spencer declared was a first sine qua non of the successful life. He was a poor animal, the poorest of animals, because he possessed poor adrenals. According to his son he rose early because he could not lie in bed, and he would have liked to get up earlier than he did. What other hints have we that in spite of his fatigue disease he was a pituitocentric?

From the strong affinity of the brain-cells for adrenalin which was manifested in our experiments we may strongly suspect that the Nissl substance is a volatile, extremely unstable combination of certain elements of the brain-cells and adrenalin, because the adrenals alone do not take the Nissl stain and the brain deprived of adrenalin also does not take Nissl stain.

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