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Updated: July 26, 2025
The clinician knows that every one of the above-mentioned causes of increased brain-cell, adrenal, liver and muscle activity may cause an increase in the activity of both the normal or the enlarged thyroid; and lie knows only too well that in a given case of exophthalmic goiter the same stimuli which excite the brain, the adrenals, the liver, and the muscles to increased activity will also aggravate this disease.
The complete data of these experiments will be later reported in a monograph; here it is sufficient to state that anger, fear, injury, muscular exertion, inhalation anesthesia, strychnin, alcohol, in fact, all the stimuli which we had already found to produce histologic changes in the brain, the adrenals, and the liver-excepting bacterial toxins caused increased H-ion concentration.
A trend to violence and a resentful emotionalism are combined with desperate attempts to spur the jaded adrenals with artificial excitements. Consequent melancholia and depression, the "blues," are inevitable. A survey of drug addicts would probably show a definite percentage of this type. The same applies to certain petty criminals and law breakers.
"Abelous, and Langlois and Albanese have studied the relation of the adrenal bodies to fatigue.... They infer that the muscular weakness following removal of the adrenals is due to toxic substances.
It can have a genetic predisposition for a specific allergy to start with. It can be repeatedly exposed to an irritating substance such as pollen when, at the same time, the body's mechanism for dealing with irritations is weakened. Generally weak adrenals causes this because the adrenal's job is to produce hormones that reduce inflammation.
Should they not, should adverse mechanical circumstances or chemical malfunction prevent, dire effects may follow. A woman with the closed-in type of pituitary, shut up in a small non-expansile sella turcica, will suffer the most violent headaches, will become fat, will frequently abort. Of adrenal insufficiency, failure of the adrenals to hypertrophy sufficiently in pregnancy, little is known.
The brain-cells and the adrenals are securely, concealed from the eye of the clinician, hence the changes produced in them by different causes escape his notice, but the thyroid has always been closely scrutinized by him.
And, as has been emphasized in preceding chapters, most neurasthenia rises upon a disturbed endocrine foundation, most often, an insufficiency of the adrenals. That is, a defect in the chain of co-operation, balance and compensation among the internal secretions is the basis for the weakness of the nervous system the term neurasthenia is supposed to explain, actually only names.
If the growth of the skull has left a roomy sella turcica for the pituitary to grow in, the intellect may be normal or even superior, though energy is below par. If this is not possible and the adrenals have to predominate, a lower, more animal and less self-controlled type of mentality is produced. In direct contrast to the subthyroid types is he who originally was hyperthyroid.
In view of our present knowledge of the physiological action of adrenaline in its various forms, it seems more probable that the weakness is to be explained by the absence of the normal tone producing internal secretions of the bodies in question." In other words, the adrenals regulate muscle tone. They produce nature's tonics for weary tissues.
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