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Gley, to whom we owe much of our knowledge of glandular action, has asserted that "the genesis and exercise of the higher faculties of men are conditioned by the purely chemical action of the product of these secretions. Let psychologists consider these facts." These internal secretions or endocrines pass directly into the blood stream, and exercise a dominating power over health and personality.

Periodic variations in the secretory tides of the other endocrines, the ovaries, the thyroid, and so on, may determine the onset of the attack of "fits."

So that, on the whole, a number of endocrines work to render woman naturally fearful, as we say. Courage is so closely related to fear and anger that all are always associated in any discussion. Courage is commonly thought of as the emotion that is the opposite of fear. It would follow that courage meant simply inhibition of the adrenal medulla.

Without enough of it to hold the uterus stimulating endocrines, particularly the post-pituitary, in check, still-birth results. If there is enough, and not too much of it, the woman will not feel ill at all, or perhaps only transiently, but will be possessed of a curious feeling of drowsy content and passive, relaxed happiness.

Just what fatigue is, why different individuals tire at different rates, why some are constructed for monotonous routine while others must have constant variety and change, the relation to accidents and to quantity output, are a few of the major lines of inquiry upon which the endocrines obviously have a large bearing.

If physically feminine due to adequate feminine reactions on the part of the other endocrines she will at least show the qualities of a psychic virilism. A generation ago, such a woman had to repress her inherent trends and instincts in the face of public opinion and law, and so suffered from a feeling of inferiority.

Though what happens at puberty, what happens all through life through the agencies of the endocrines is amazing enough, what occurs during the period of child-bearing is perhaps the most amazing of all. As emphasized, pregnancy is the time, among the internal secretions, of a great uprooting and stirring, of fundamental and cataclysmic changes in the most intimate chemistry of the cells.

The dictum of the founder of modern pathology, Virchow, that Woman was in effect an appendix to the ovaries, has long been taken to apply to her psychic traits as well as somatic. Her mind, like her skin, her hair and her pelvis, is a product of the ovarian endocrines. But these determinations are by no means her monopoly.

If human life, in its essentials, is so much the product of the internal messenger system we speak of as the endocrines, then biography should present us with a number of illustrations of their power and influence.

The endocrines will assist him in the great body of diseases for which no immunity test is at hand. Should another influenza epidemic come along, for instance, the proper handling, from the endocrine standpoint, of the thymocentrics and the related adrenocentrics would help considerably in lowering the mortality.