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Updated: June 7, 2025
Despite these desperate attempts at suicide he lived several months, finally accomplishing his purpose by taking an overdose of morphin. MacQueen has given the history of a man of thirty-five, who drove one three-inch nail into his forehead, another close to his occiput, and a third into his vertex an inch in front and 1/4 inch to the left of the middle line.
Nowhere else in the body should pain be so speedily combated as when it occurs in the region of the heart. Morphin, with or without atropin, as deemed best, should be administered hypodermically in the amount and with the frequency necessary to stop the pain and quiet the restlessness. As stated above, the frequent need for morphin may be prevented by use of the ice bag.
Oxygen does not cure pneumonia, but may relieve a dyspnea and aid a heart until other drugs have time to act. If there is insomnia, morphin in small doses will not only cause sleep, but also not hurt the heart. In the morning hours of the day the value of caffein as a cardiac stimulant and vasocontractor, either in the form of caffein or as black coffee, should be remembered.
The consumption of the Nissl substance in the brain-cells is lessened or prevented by morphin, as is the output of adrenalin; and the consumption of the Nissl substance is also lessened or prevented by nitrous oxid. But morphin does not prevent the action of adrenalin injected into the circulation, hence the control of morphin over energy expenditure is exerted directly on the brain-cells.
The patient remained conscious and calm throughout; finally deep anesthesia was produced by ether and chloroform, three and a half hours after the accident, and in twenty minutes the intestines were all replaced in the abdominal cavity. The edges were pared, sutured, and the wound dressed. The woman was placed in bed, on the right side, and morphin was administered.
In our experiments no increase in the H-ion concentration was produced by morphin or by scopolamin, no matter how deep the narcotization. In animals already narcotized by morphin the production of acid by any of the acid-producing stimuli was delayed or prevented.
You know I don't mean to say anything that will reflect on your specialty, but you never did see a case of only nerves put a healthy young girl in bed and keep her there suffering so that I've had to give her aspirin a hundred times and even morphin by hypodermic to get her quiet, and off and on for five years she's had ten, and sometimes fifteen grains of veronal at midnight, nights when she couldn't get to sleep.
In these vomiting and collapse cases the hypodermic administration of morphin and atropin will not only stop the vomiting, at least temporarily, but will also give necessary rest. The dose of morphin need not be large, and the atropin may prevent nausea from the drug.
Yet these weeks and months of development may never be, for in a short time he will again be legally accountable, and probably will resent and refuse constructive discipline, and return to a satin-upholstered life his cigarettes, his wine-dinners, his liquors, and his "rotten feeling" mornings after then to his morphin and to his certain degradation. And why should this be?
Apparently morphin and nitrous oxid both act through this interference with oxidation in the brain. We, therefore, conclude that within a certain range of acidity of the blood adrenalin can unite with the brain-cells only through the mediation of oxygen, and that the combination of adrenalin, oxygen, and certain brain-cell constituents causes the electric discharge that produces heat and motion.
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