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Updated: May 14, 2025
When there is early and pronounced general intoxication, there is likely to be confusion with other acute febrile illnesses, such as scarlet fever. In all febrile conditions in children and adolescents, the ossifying junctions of the long bones should be examined for areas of pain and tenderness.
Tenderness on pressure over the bone is the most valuable diagnostic sign. At a later stage there is an ill-defined swelling in the region of the ossifying junction, with œdema of the overlying skin and dilatation of the superficial veins. The swelling appears earlier and is more definite in superficial bones such as the tibia, than in those more deeply placed such as the upper end of the femur.
Her eyes flashed as she spoke, and the little womanly body, whose highest flight had seemed to end in a London frock and petticoat, had suddenly become something much more than he had fancied possible to her. She had taken the first place, and he felt himself overshadowed. He looked up at her with a sort of reverence, but he held stubbornly to a purpose that had been ossifying for twenty years.
It was hard to swallow the coffee, took effort to force it down a channel that was suddenly narrowed to a parched, resistent tube. She would answer no one, seemed to have undergone an ossifying of all faculties turned to the sounds and sights of life. David remembered her state when the doctor had been ill on the Platte.
She can do it more easily than she can stay at home, watch half her friends marry, and feel herself slowly ossifying into something worthless and unessential. It takes more courage to sit quietly, wait for what may never come, and observe without misgiving the man you might have had making some other woman's life happy and complete. I couldn't go on living in guest-rooms forever.
The nutrient artery, after entering the medullary canal through a special foramen in the cortex, bifurcates, and one main division runs towards each of the extremities, and terminates at the ossifying junction in a series of capillary loops projected against the epiphysial cartilage.
Ultimately the dead bone becomes loose and lies in a cavity a little larger than itself; the wall of the cavity is formed by the new case, lined with granulation tissue. The separation of the sequestrum takes place more rapidly in the spongy bone of the ossifying junction than in the compact bone of the shaft.
In periosteal tumours that do not ossify, there is merely erosion of bone, and the shadow is not unlike that given by caries; in ossifying tumours, the arrangement of the new bone on the surface is characteristic, and when it takes the form of spicules at right angles to the shaft, it is pathognomic.
Palma threw it on the table, and as he glanced from the lovely countenance of the girl to that of the woman on the wall, something like a sigh heaved his broad chest. Did the wan meek shadow of his own patient much-suffering young mother lift her melancholy image in the long silent adytum of his proud heart, over whose chill chambers ambition and selfishness had passed with ossifying touch?
Conversely, excessive growth of bone at the ossifying junctions results in abnormal height of the skeleton or giantism as a result, for example, of increased activity of the pituitary in adolescents, and in eunuchs who have been castrated in childhood or adolescence; in the latter, union of the epiphyses at the ends of the long bones is delayed beyond the usual period at which the skeleton attains maturity.
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