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Updated: May 18, 2025
A beginning of this study of endocrine inheritance, on the pathologic side, has been made. Some of these have been along Mendelian lines. If an endocrine abnormality like a goitre, or cretinism, or a dwarf or giant appear in a family as a sign of endocrine instability, other members of that family will very likely show internal secretion abnormalities.
One wretched hovel succeeded another. Yonder before a door, Wilhelm the idiot, on whom the city boys played their pranks, smiled into vacancy just as foolishly as he had done twenty years ago, here lodged Kathrin, with the big goitre, who swept the gutters; in the three grey huts, from which hung numerous articles of ragged clothing, lived two families of charcoal-burners, and Caspar, the juggler, a strange man, whom as a boy he had seen in the pillory, with his deformed daughters, who in winter washed laces and in summer went with him to the fairs.
She is a tall, full woman of forty-six, with chestnut hair, and a fat goitre of three chins. Her eyes are encircled with black rings of hemorrhoidal origin. The face broadens out like a pear from the forehead down to the cheeks, and is of an earthen colour; the eyes are small, black; the nose humped, the lips sternly pursed; the expression of the face calmly authoritative.
Bowed down by toil, stolid with ignorance, disfigured with the goitre, struck with cretinism, the miserable beings around you do more to sadden you than all that the bright air and glorious hills can do to exhilarate you. The valley where we now were was a complete cul de sac. It was walled in all round by limestone hills of great height, and the eye sought in vain for visible outlet.
The following remarks on a well-known disease are extracted from Dr. Richardson's Journal: "Bronchocele, or Goitre, is a common disorder at Edmonton. I examined several of the individuals afflicted with it, and endeavoured to obtain every information on the subject from the most authentic sources. The following facts may be depended upon.
On the Rigi his musings on the magnificence of the view are checked by the presence of a cretin. Behold the contrast! An idiot with a goitre and an enormous face, a blank stare, and a stupid laugh is sole participator with Victor Hugo in this "marvellous festival of the mountains." "Oh! abysm!" he cries; "the Alps were the spectacle, the spectator was an idiot!
Goitre, not too vascular in character, is removed by a longitudinal incision over the tumor, after which the gland is to be dragged out, with its entire capsule, by means of a blunt hook. A large goitre in a feeble patient, however, is better left alone, as it is difficult to remove all the intricate roots of the tumor, and if any portion is left it is prone to return.
You've rooked 'em, chiselled 'em out of a lot of cash, too. There was old Lamson fifteen hundred for the goitre on his neck; and Mrs. Gilligan for the cancer two thousand, wasn't it? Tincture of Lebanon leaves you called the medicine, didn't you? You must have made fifty thousand or so in the last ten years."
The thyroid body, situated in the neck and the enlargement of which is called goitre, secretes substances which pass into the blood, and which are necessary for the growth of the body in childhood, for the development of the mind and for the nutrition of the tissues of the skin.
Two important factors in the demand for them are the large preponderance in the number of males at the capital, and the prevalence there of goitre or thick neck, a deformity which is absent from the district of Chaotong. Infanticide in a starving city like this is dreadfully common.
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