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Updated: June 8, 2025
N.B. The case alluded to, in the last of the above replies, was, in the first instance, papular eruption; the base of each papula being surrounded by an inflamed ring; the eruption was thickest on the thorax, and on the arms; in its progress, the eruption became pustular, the pustules being in circumference about half the usual size of the vaccine vesicle; on the twelfth day, the crusts had dropped from some of the smaller pustules; and, by the seventeenth day, they had all dropped off, leaving a mark, but not in any manner pitted; and which, I think, promises to be permanent.
This cultivation of a virus within the animal organism suggested, no doubt, by the familiar Jennerian method of securing small-pox vaccine, was at the same time a step in the direction of a new therapeutic procedure which was destined presently to become of all-absorbing importance the method, namely, of so-called serum-therapy, or the treatment of a disease with the blood serum of an animal that has been subjected to protective inoculation against that disease.
This latter is the cow-pox, from which Jenner derived the vaccine matter. Treatment. Foment the teats well with warm water and Castile-soap; after which, wipe the bag dry, and dress with citrine ointment. The preparations of iodine have also been recommended, and they are very serviceable.
Where the idea came from I can not conceive. It was practiced by the Bakwains at a time when they had no intercourse, direct or indirect, with the southern missionaries. They all adopt readily the use of vaccine virus when it is brought within their reach.
Experiments, similar in principle to those of Helmholtz on fermentation and putrefaction, have proved that the active element in the vaccine lymph is non-diffusible, and consists of minute particles not exceeding 1/20000th of an inch in diameter, which are made visible in the lymph by the microscope.
Carbohydrate starvation is inexcusable with our present understanding of the danger from acideinia, and even from a diminished amount of alkalies in the blood. The cause of pericarditis being so varied, any anti-toxin treatment or any vaccine treatment could be indicated only if the cause of the inflammation rendered the serum or vaccine advisable. Stopping the Pain.
'While the vaccine discovery was progressive, he writes, 'the joy at the prospect before me of being the instrument destined to take away from the world one of its greatest calamities, blended with the fond hope of enjoying independence, and domestic peace and happiness, were often so excessive, that, in pursuing my favorite subject among the meadows, I have sometimes found myself in a kind of reverie.
Success has attended the use of a vaccine prepared from cultures of the organism; and the X-rays and radium, combined with the administration of iodides in large doses, or with intra-muscular injections of a 10
If marked constitutional disturbance with rise of temperature follows the use of a vaccine, it indicates a negative phase, and calls for a diminution in the next dose. If, on the other hand, the local as well as the general condition of the patient improves after the injection, it indicates a positive phase, and the original dose may be repeated or even increased.
The principal variation perceptible to me in the action of the vaccine virus generated in London from that produced in the country was its proving more certainly infectious and giving a less disposition in the arm to inflame. There appears also a greater elevation of the pustule above the surrounding skin.
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