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Updated: June 9, 2025
The facts concerning cryptorchidism, that is to say, failure of the descent of the testes in Mammals, seem to show that the hormone of the testis is not derived from semen or spermatogenesis, for in the testes which have remained in the abdomen there is no spermatogenesis, while the interstitial cells are present, and the animals in some cases exhibit normal or even excessive sexual instinct, and all the male characteristics are well marked.
Sometimes, the milk is greatly changed in appearance, is foul smelling and contains pus. In congestion of the udder and rupture of the capillary vessels, the milk may contain blood. Mild inflammation of the udder responds readily to treatment. The interstitial form may terminate in abscesses and gangrene.
In such cases it is essential that they should receive the interstitial glands of the male goat. We have in hospital at the moment, however, a childless married woman of twenty-eight, who wishes devoutly for a female child. We found her sterile of a natural gland and inserted the gland of a female goat. Her transformation has been remarkable, and I am confident her first child will be a girl.
There was an acute parenchymatous nephritis with focal plasma cell infiltrations suggesting acute interstitial nephritis. This case appears to have shown one of the most nearly normal brains in the whole Danvers series. Patient was variously designated, as "dementia" and as "acute confusional insanity." Father also insane.
They are something far more interstitial, so to speak, than what my feelings record. The real facts of activity that have in point of fact been systematically pleaded for by philosophers have, so far as my information goes, been of three principal types. The first type takes a consciousness of wider time-span than ours to be the vehicle of the more real activity.
Often in serums the poison elements are retained, but not the nutritive. We use the whole goat gland, as a rule, because we do not know in what part of it the hormones hide. The attempted transplantations of kidneys have thus far failed because the kidney product is waste matter, not live cells as in the case of the interstitial glands.
Sex libido is an expression of a certain concentration, a definite amount peculiar to the individual, of the substance manufactured by the interstitial cells, circulating in the blood.
A vitality is created which makes him bound and dart like a youth of his species. In due time, though, senility returns. It is as if a storage battery, recharged, runs down and becomes dead again. Slitting the genital duct of the other testis, causing its interstitial cells to hypertrophy and multiply, repeats the effects of the first experiment.
These so-called secondary sexual characteristics are an expression of the influence of the internal secretion of the gonads, or the interstitial glands. Some call them puberty glands, because their ripening initiates puberty. Castration was probably the first surgical operation carried out for experimental purposes, suggested no doubt by a curiosity concerning its effects.
So much of the phenomena of volcanoes as has been above noted is intended to show the large part which interstitial water plays in volcanic action. We shall now turn our attention again to the state of the deeply buried rock water, to see how far we may be able by it to account for these strange explosive actions.
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