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Updated: June 9, 2025


In all of these the administration of the respective internal secretions increases the burning up of material in the body, and all of them have a higher rate of tissue combustion than their confreres, with a subthyroid or subpituitary keynote in their cell chemistry, or with insufficient interstitial cell action. Generally the latter have a very dry skin, the former a moist skin.

It is therefore the book of man; for all men are idlers; we have hours which we pass with lamentation, and which we know are always returning. At those moments miscellanists are conformable to all our humours. We dart along their airy and concise page; and their lively anecdote or their profound observation are so many interstitial pleasures in our listless hours.

J. R. Brinkley, head of the Brinkley-Jones Hospital and Training School for Nurses at Milford, Kansas, has now furnished to the scientific world what are termed "ample proof cases" that by implantation of the fresh interstitial glands of the goat sterile people may bear children of either sex desired. Already the town is filling up with childless people waiting to be operated upon.

The thyroid gland and parathyroids, for instance, seem to be connected by some close sympathy with the activity or non-activity of the interstitial glands, and the atrophy of one is often accompanied by the atrophy of the other.

Of course it should be repeatedly emphasized that chronic interstitial nephritis may be in evidence with either albumin or casts alone, or without either being present. Janeway sums up his conclusions by stating that "from the time of the development of symptoms indicative of cardiovascular or renal disease, four years will witness the death of half the men and five years of half the women.

Eunuchs and eunuchoids, that is, individuals with insufficient internal secretion of the interstitial cells, have longer bones and more fragile bones than the normal. Vice versa, those with an excess of the secretion have shorter and thicker bones.

A similar enlargement is met with in the axilla in cases of chronic interstitial mastitis, and in the groin as a result of chronic irritation about the external genitals, such as balanitis. Sometimes the lymphadenitis is of an acute character, and the tendency is towards the formation of an abscess.

In renal insufficiency associated with cardiac insufficiency, its action is subject to careful watching. If there is marked advanced interstitial nephritis, digitalis may not work satisfactorily and must be used with caution. If, on the other hand, a large part of the kidney trouble is due to the passive congestion caused by circulatory weakness, digitalis will be valuable.

When we speak of the feminine we really mean the predominantly feminine. And when we speak of the masculine, we mean the mainly masculine. Between, all sorts of transitions are possible and occur. Man in relation to the internal secretions we have considered in reviewing the interstitial cells. To him, we shall return later. Let us turn now to that fascinating subject of the ages, Woman.

Sooner or later these irritants cause kidney irritation, and chronic interstitial nephritis may develop. just which process becomes the farthest advanced and finally kills the patient is an individual proposition and cannot be foretold. The finale may be cirrhosis of the liver, uremia, arteriosclerosis, apoplexy or myocarditis with dilatation or coronary disease.

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