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Updated: May 1, 2025
The facts concerning cryptorchidism, that is to say, failure of the descent of the testes in Mammals, seem to show that the hormone of the testis is not derived from semen or spermatogenesis, for in the testes which have remained in the abdomen there is no spermatogenesis, while the interstitial cells are present, and the animals in some cases exhibit normal or even excessive sexual instinct, and all the male characteristics are well marked.
Other qualities, likewise, are resultants of a compromise between all the endocrine factors comprising the equation of the individual. If we are to look for unit factors at all in endocrine heredity, we must look more deeply into constitution, and measure the hormone potentials and their mobilization or suppression.
If the foetal hormone is absorbed from the pouch, as I have suggested, in order to explain the persistence of the corpora lutea during lactation, then the secretion of milk after parturition ought not to take place.
The bone also begins to die when the skin and periosteum is stripped off, and the hormone from this also ceases to be produced. The annual shedding and recrescence of the antler, however, is only to be understood in connexion with the effect of the testicular hormone.
The factors in these chromosomes corresponding to the forehead have been stimulated while in the parent animal by hormones from the outgrowth of tissue produced by external mechanical stimulation, while at the same time they were permeated by the testicular hormone produced either by the gametocytes themselves or by interstitial cells of the testis.
It might be agreed that if the determinants are stimulated or deprived of stimulation, the effect of the change should logically show itself from the beginning of development, and that therefore the process of metamorphosis or indirect development does not support the hormone theory any more than the theory of gametogenic mutations. This objection may be answered in the following way.
Nowadays, we see its domain as a limited monarchy, if not indeed as one sovereign state of a republic, a member equal but not superior to the others of a board of directors. Its true business comes down to two particular rôles: first, the production of ova, and, second, the secretion of a hormone or hormones. Over the other functions once supposed its monopoly, all the ductless glands rule.
But in this, as in other cases, the hereditary result is regular, constant, and symmetrical, while the immediate effect on the individual is doubtless irregular. Mammalian Sexual Characters Evidence Opposed To The Hormone Theory
As vital force drops, the overall efficiency of all the body's organs correspondingly decline. The pancreas creates less digestive enzymes; the thymus secretes less of its vital hormones that mobilize the immune system; the pituitary makes less growth hormone so the overall repair and rebuilding of cells and tissues slows correspondingly; and so forth.
The masculinoid woman, as a functional hermaphrodite, exists first as a congenital entity, with an inborn distribution of endocrine predominances that make for masculinity. There are also numerous acquired forms. The infections of childhood, measles, scarlet fever, diphtheria, and above all mumps, may so damage the hormone system that an inversion of sex type follows.
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