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Updated: June 22, 2025
In the first case, it provides the muscle-cell with a large reserve deposited in advance: the quantity of glycogen contained in the muscles is, indeed, enormous in comparison with what is found in the other tissues.
A human body is estimated to yield on an average about 18 per cent of albuminous substances. The Carbohydrates are formed of carbon, hydrogen, and oxygen, the last two in the proportion to form water. Thus we have animal starch, or glycogen, stored up in the liver. Sugar, as grape sugar, is also found in the liver. The body of an average man contains about 10 per cent of Fats.
The placenta shows a real affinity for some toxic substances; in it accumulate copper and mercury, but not lead, and it is therefore through it that the poison reaches the fetus; in addition to its pulmonary, intestinal, and renal functions, it fixes glycogen and acts as an accumulator of poisons, and so resembles in its action the liver; therefore the organs of the fetus possess only a potential activity.
In a sense the storage of fat by connective tissue cells and of glycogen by the liver cells is assimilation. The term is limited, however, to the disposition of material with reference to its final use. Whether all the materials used by the cells actually become a part of the protoplasm is not known.
While the chief work of the liver is perhaps not that of excretion, its functions may here be summarized. The liver is, first of all, a manufacturing organ, producing, as we have seen, three distinct products—bile, glycogen, and urea.
The vein which transmits the blood from the intestines to the liver had the usual lower percentage of sugar corresponding to the analysis established for the other veins. The liver, therefore, must add sugar to the blood on its way to the heart. Extraction of the liver then revealed the presence in it of a form of starch, an animal starch, which Bernard called glycogen, the sugar-maker.
The increased action of the muscles of the heart and the blood-vessels increases the efficiency of the circulation; the secretion of the adrenal gland causes a rise in the blood-pressure; the increased action of the thyroid gland causes an increased metabolic activity; there is evidence that glycogen is actively called out, this being the most immediately available substance for the production of energy; the increased activity of the respiration is needed to supply the greater need of oxygen and the elimination of the increased amount of waste products; the dilatation of the nostrils affords a freer intake of air; the increased activity of the sweat-glands is needed to regulate the temperature of the body which the increased metabolism causes to rise.
For example, the output of adrenalin is increased, and, as a consequence, arteriosclerosis and cardiovascular disease may occur in persons who have been subjected to prolonged emotional strain, since it has been proved that the prolonged administration of adrenalin will cause these conditions. We have stated that the emotions cause increased output of glycogen.
Gluten. The glutinous albuminoid ingredient of cereals. Glycogen. Literally, "producing glucose." Animal starch found in liver, which may be changed into glucose. Gram. Unit of metric system, 15.43 grains troy. Groin. The lower part of the abdomen, just above each thigh. Belonging to the sense of taste. The practice of athletic exercises.
More particularly, it is from the sensori-motor system that the call for glycogen, the potential energy, comes, as if the rest of the organism were simply there in order to transmit force to the nervous system and to the muscles which the nerves control.
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