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Updated: June 26, 2025
After growth has been finished, that is, after adolescence, these zones of ossification close, so that growth is no longer possible unless they become reactivated. Upon the zone of ossification must act the pituitary, and indirectly the thyroid, the interstitial cells, the thymus and the adrenals.
If, however, the cortex is invaded, as happens most often in the classical tuberculosis of the adrenals which drew the attention of the Englishman Addison to them, then a darkening of the skin, which may go on to a negroid bronzing, follows. That means an increased sensitiveness of the pigment cells of the skin to light.
An animal, both of whose adrenals had been excised, showed no hyperchromatism in the brain-cells after the injection of strychnin, toxins, foreign proteins, etc.
As the gland of acute stress and strain, the adrenals in modern life are called upon to function more heavily and frequently than in the past. As a matter of fact, the life of the beast of jungle and field, as well as of savage and barbarian, is just as full of emergencies and shocks as that of the average city man or woman.
One fact should be noted. When the adrenals evoke precocity, and an early awakening of the secondary sex characteristics, it is a masculine precocity, and an approximation to the masculine even in females. There is a definite trend toward an increase of the male in the individual's composition at the expense of the female.
If the activities are consummated, the fuel glycogen and the activating secretions from the thyroid, the adrenals, the hypophysis are consumed. In the activation without action, these products must be eliminated as waste products and so a heavy strain is put upon the organs of elimination.
But unlike other drugs used to stimulate the heart, at any reasonable dose Q-10 has no harmful side effects. It also tends to give people the extra pick up they are trying to get out of a cup of coffee. But Q-10 does so by improving the function of every cell in the body, not by whipping exhausted adrenals like caffeine does.
Bearing especially on this point is the fact that if adrenalin in sufficient quantities be administered simultaneously with an acid, it will not only prevent the fall in blood-pressure usually caused by the acid, but will also prevent the histologic changes in the brain, adrenals, and liver which are usually caused by the intravenous injection of acids.
With these three kinetic organs we may surely associate also the "furnace," the muscles, in which the energy provided by the brain, adrenals, and liver, plus oxygen, is fabricated into heat and motion. Benedict, in his monumental work on metabolism, has demonstrated that in the normal state, at least, variations in the heart-beat parallel variations in metabolism.
From these studies we are forced to conclude not only that the brain and adrenals are interdependent, but that the brain is actually more dependent upon the adrenals than the adrenals upon the brain, since the brain deteriorates progressively to death without the adrenals, while the adrenal whose connection with the brain has been broken by the division of its nerve supply will still produce sufficient adrenalin to support life.
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