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Updated: June 24, 2025
As the malady had shewn itself in so slight a manner, and as it had taken place at so distant a period of her life, I was happy with the opportunity of trying the effects of variolous matter upon her constitution, and on the 28th of March, 1797, I inoculated her by making two superficial incisions on the left arm, on which the matter was cautiously rubbed.
Dr. As to Dr. Jenner's discovery of vaccination, he was less favorably disposed to it; he apprehended dangerous consequences from the absorption of a brutal miasma into the human blood, or at least into the lymph; and at any rate he thought, that, as a guarantee against the variolous infection, it required a much longer probation.
The skin, we know, is ever ready to exhibit, though often in a very limited degree, the effects of the poison when inserted there; and how frequently do we see, among nurses, when much exposed to the contagion, eruptions, and these sometimes preceded by sensible illness! yet should any thing like an eruption appear, or the smallest degree of indisposition, upon the insertion of the variolous matter on those who have gone through the cow-pox, my assertions respecting the peculiarities of the disease might be unjustly discredited.
Some patients inoculated on the same day with variolous matter have considerable inflammation. 17. The discoloration is quite gone in them all, and from my own hand, a dry mark only remaining. And they were all inoculated on the 18th, with variolous matter, which produced the disease in them all." Mr.
A portion of a drop applied with the head of a probe or any convenient utensil upon the pustule, suffered to remain about forty seconds, and afterwards washed off with sponge and water, never failed to stop its progress and expedite the formation of a scab. "I have already subjected two hundred and eleven of my patients to the action of variolous matter, but EVERY ONE RESISTED IT. "In Dr.
In the common course of inoculation previous to the general one scarcely a year passed without my meeting with one or two instances of persons who had gone through the cow-pox, resisting the action of the variolous contagion.
Although I say the system may at any time be made to feel the febrile attack of cow-pox, yet I have a single instance before me where the virus acted locally only, but it is not in the least probable that the same person would resist the action both of the cow-pox virus and the variolous. Elizabeth Sarfenet lived as a dairymaid at Newpark farm, in this parish.
Whether it be yet ascertained by experiment that the quantity of variolous matter inserted into the skin makes any difference with respect to the subsequent mildness or violence of the disease, I know not; but I have the strongest reason for supposing that if either the punctures or incisions be made so deep as to go through it and wound the adipose membrane, that the risk of bringing on a violent disease is greatly increased.
On the second day after the operation, the punctured parts were inflamed, though I think the arm in which I had inserted variolous matter was rather more so than the other. On the third the inflammation was increased, and looked much the same as in the preceding experiment. 4th. The inflammation was much diminished, and on the 5th almost gone.
This experiment was made to ascertain the progress and subsequent effects of the disease when thus propagated. We have seen that the virus from the horge, when it proves infectious to the human subject, is not to be relied upon as rendering the system secure from variolous infection, but that the matter produced by it upon the nipple of the cow is perfectly so.
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