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Updated: June 24, 2025
He was exposed at the same time to the natural infection, but has continued perfectly well. "On the 23d I introduced blood into the arms of three more children, taken on the third and fourth days of the eruption. The appearances were much the same as mentioned in experiments first and third. They were afterwards inoculated with variolous matter, and had the disease in the regular way.
Thus in the natural small-pox the contagion is swallowed with the saliva, and by its stimulus inflames the stomach; this variolous inflammation of the stomach increases every day, like the circle round the puncture of an inoculated arm, till it becomes great enough to disorder the circles of irritative and sensitive motions, and thus produces fever-fits, with sickness and vomiting.
But when these new motions of the vascular muscles are exerted with greater violence, and these vessels are either elongated too much or too hastily, a new material is secreted from their extremities, which is of various kinds according to the peculiar animal motions of this new kind of gland, which secretes it; such is the pus laudabile or common matter, the variolous matter, venereal matter, catarrhous matter, and many others.
Although the skin, for example, adipose membrane, or mucous membranes are all capable of producing the variolous virus by the stimulus given by the particles originally deposited upon them, yet I am induced to conceive that each of these parts is capable of producing some variation in the qualities of the matter previous to its affecting the constitution.
The same unfortunate circumstance of giving a disease, supposed to be the smallpox, with inefficacious variolous matter, having occurred under the direction of some other practitioners within my knowledge, and probably from the same incautious method of securing the variolous matter, I avail myself of this opportunity of mentioning what I conceive to be of great importance; and, as a further cautionary hint, I shall again digress so far as to add another observation on the subject of inoculation.
On this day the inflammation was somewhat greater, and the cuticle rather elevated. "24th. Inflammation much less, and only a brown or orange-colour remained. 25th. Scarcely any discoloration left. On this day he was inoculated with variolous matter, the progress of the infection went on in the usual way, and he had the small-pox very favourably.
I took some blood from a vein in the arm of a person who had the small-pox, on the second day of the eruption, and introduced a small quantity of it immediately with the point of a lancet between the scars and true skin of the right arm of a boy nine years old in two or three different places; the other arm was inoculated with variolous matter at the same time. "19th.
I never saw nor heard of an instance of its being confluent. The most accurate manner, perhaps, in which I can convey an idea of it is by saying that had fifty individuals been taken promiscuously and infected by exposure to this contagion, they would have had as mild and light a disease as if they had been inoculated with variolous matter in the usual way.
"Morbid matter of various kinds, when absorbed into the system, may produce effects in some degree similar; but what renders the cow-pox virus so extremely singular is that the person that has been thus affected is forever after secure from the infection of small-pox, neither exposure to the variolous effluvia nor the insertion of the matter into the skin producing this distemper."
Woodville, have ever been produced by the pure uncontaminated cow-pock virus; on the contrary, I do suppose that those which the doctor speaks of originated in the action of variolous matter which crept into the constitution with the vaccine. Another circumstance strongly, in my opinion, supporting this supposition is the following: The cow-pox has been known among our dairies time immemorial.
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