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I advised her by all means to have them inoculated at that time, as I could not procure any variolous matter elsewhere. However, they were inoculated with vaccine matter, but I cannot say I flattered myself with its proving successful, as they had previously been so long and still continued to be exposed to the variolous infection.
February the 13th, 1797, I availed myself of an opportunity of inoculating William Rodway, the servant man above alluded to. Variolous matter was inserted into both his arms: in the right, by means of superficial incisions, and into the left by slight punctures into the cutis. Both were perceptibly inflamed on the third day.
Woodville, who also has favoured me with an account of his more extensive inoculation with the same virus at the Smallpox Hospital, it appears that many of their patients have been affected with eruptions, and that these eruptions have maturated in a manner very similar to the variolous.
7th: A perceptible vesicle: this evening the patient became a little chilly; no pain or tumour discoverable in the axilla. 8th: Perfectly well. 9th: The same. 10th: The vesicle more elevated than I have been accustomed to see it, and assuming more perfectly the variolous character than is common with the cow-pox at this stage.
Something similar to this is seen in the secondary fever of the confluent small-pox; there is a great absorption of variolous matter, a very minute part of which would give the genuine small-pox to another person; but here it only stimulates the system into common fever; like that which common puss, or any other acrid material might occasion.
I must confess I was now greatly alarmed, although I had been much engaged in the smallpox, having at different times inoculated not less than two thousand persons. I was convinced my present indisposition proceeded from the insertion of the variolous matter, and, therefore, anxiously looked for an eruption.
His right hand had only one small tumour upon it, and no sore discovered itself in the corresponding axilla. In the year 1792 Stinchcomb was inoculated with variolous matter, but no consequences ensued beyond a little inflammation in the arm for a few days. A large party were inoculated at the same time, some of whom had the disease in a more violent degree than is commonly seen from inoculation.
On the fourth day the inflammation was evidently subsiding, and on the sixth day it was scarcely perceptible. No symptom of indisposition followed. "To convince myself that the variolous matter made use of was in a perfect state I at the same time inoculated a patient with some of it who never had gone through the cow-pox, and it produced the smallpox in the usual regular manner."
From the preceding observations on the matter of smallpox when decomposed it must, I conceive, be admitted that cow-pox matter in the state now described may produce a disease, the effects of which may be felt both locally and generally, yet that the disease thus induced may not be effectual in obviating the future effects of variolous contagion. In the case of Mary Miller, related by Mr.
As well as the perfect change from that state in which variolous matter is capable of producing full and decisive effects on the constitution, to that wherein its specific properties are entirely lost, it may reasonably be supposed that it is capable of undergoing a variety of intermediate changes.
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