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Updated: June 8, 2025
From the addition of a sufficient number of leucocytes, the contents may resemble the pus of an ordinary abscess. The wall of the abscess is lined with tuberculous granulation tissue, the inner layers of which are undergoing caseation and disintegration, and present a shreddy appearance; the outer layers consist of tuberculous tissue which has not yet undergone caseation.
The manufacture of sugar has also been tried on the island, but although the cane succeeds uncommonly well, the expense of conveying it to Funchal, together with that of the process of extracting the juice, and the want of skill in granulation, has rendered the experiment too costly, it being found that Brazilian sugar can be had cheaper than the native production. Sunday, August 12th, 1827.
#Granulation Tissue.# The essential and invariable medium of repair in all structures is an elementary form of new tissue known as granulation tissue, which is produced in the damaged area in response to the irritation caused by injury or disease.
Compared to it we were as a pair of Hop-o'-my-Thumbs to the Giant; had it been man-shaped we would have come less than a third way up to its knees. I focussed my attention upon the twenty-foot-wide square that was the Keeper's foot. Its surface was jewel smooth, hyaline yet beneath it was a suggestion of granulation, of close-packed, innumerable, microscopic crystals.
The subsequent degeneration and death of the granulation tissue under the necrotic influence of bacterial toxins results in disintegration and crumbling away of the trabecular framework of the portion of bone affected. Clinically, carious bone yields a soft grating sensation under the pressure of the probe. The macerated bone presents a rough, eroded surface.
If, however, at the inauguration of the tuberculous disease the bacilli prevail, the infection tends to spread into the tissues surrounding those originally infected, and more and more tuberculous granulation tissue is formed. Finally the tuberculous tissue breaks down and liquefies, resulting in the formation of a cold abscess.
When three or four of these strings or pieces are ready, put them together, and with a knife cut the whole off in small grains. Place these grains on a sheet of paper in a warm place, and they will soon dry. During granulation, the dough must be prevented from sticking, by using a little of the dry compound powder.
The tuberculous granulation tissue is liable to break down and lead to the formation of a cold abscess and sinuses, and in our experience is often associated with disease in an adjacent bone or joint. In the peronei tendons, for example, it may result from disease of the fibula or of the ankle-joint.
They were the granulation of bricks and mortar and earth mixed by the blasts of shell fire which crushed solids into dust and splintered splinters. Guillemont lay beyond Trônes Wood across an open space where the German guns had full play.
The infection not only spreads along the medulla, but it invades the spongy bone surrounding this, and then the cortical bone, and is only prevented from reaching the soft parts by the new bone formed by the periosteum. The bone is replaced by granulation tissue, and disappears, or part of it may become sclerosed and in time form a sequestrum.
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