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Updated: June 19, 2025
This disease in a slighter degree, or when only a part of the kidney is affected, is succeeded by partial inflammation of the kidney in consequence of previous torpor. In that case greater actions of the secretory vessels occur, and the nucleus of gravel is formed by the inflamed mucous membranes of the tubuli uriniferi, as farther explained in its place.
Given the internal secretory composition, so to speak, of an individual his endocrine formula and so his intravisceral pressures, one may predict, within limits, his physical and psychic make-up, the general lines of his life, diseases, tastes, idiosyncrasies and habits.
The secretory impulses are more or less continuous and as a result, these glands secret continuously and become periodically distended as described above.
If this ingurgitation of spirituous liquors has been daily continued in considerable quantity, and is then suddenly intermitted, a languor or paralysis of the common bile-duct is induced; the bile is prevented from being poured into the intestines; and as the bilious absorbents are stimulated into stronger action by its accumulation, and by the acrimony or viscidity, which it acquires by delay, it is absorbed, and carried to the receptacle of the chyle; or otherwise the secretory vessels of the liver, by the above-mentioned stimulus, invert their motions, and regurgitate their contents into the blood, as sometimes happens to the tears in the lachrymal sack, see Sect.
But if one is a male and the other a female, the male secretory balance dominates the female in a very peculiar fashion. The female reproductive system is largely suppressed. She even develops certain male organs, and her general bodily appearance is so decidedly masculine that until Dr Lillie worked out the case she had always been supposed to be a non-functional male. She is sterile.
The same substances diffusing from the ovum during its development in the uterus would continue to stimulate the follicle cells, and thus explain not merely their persistence, but their secretory activity. The ovum being no longer present in the ovary, the secretions would remain in the follicular cells, and the corpus luteum would be explained.
Taken as a whole this is often called the "secretory balance" or "internal secretory balance." This balance is literally the key to the sex differences we see, because it lies back of them; i.e., there are two general types of secretory balance, one for males and one for females.
If, on the contrary, new eggs are continually secreted by the ovaries, it is equally evident that the secretory action must, sooner or later, become exhausted by the over excitement caused by the indulgence above mentioned. Another very great cause of sterility, and which must be of frequent occurrence, is found in the obstructed or choked-up state of the Fallopian tubes.
Only within the past few years have the general phenomena of intersexuality been cleared up to any considerable extent naturally on the basis of the secretory explanation of sex. This secretory or endocrine idea has also given us an entirely new view of sex differences. These are best discussed as functional rather than as structural.
It should be remembered, however, that the experience here recorded is that resulting from years of large and uninterrupted use of opium. The entire system had necessarily conformed itself to the artificial habit. For years the proper action of the nervous, muscular, digestive, and secretory system had been impeded and forced in an unnatural direction.
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