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With delayed involution of the pineal, obesity results. The elasticity of the skin is another quality that varies with the concentration in the blood of the internal secretions. Elasticity of the skin, its recoil upon being stretched like a rubber band, may be taken as a measure of the activity of all the endocrine glands.
An internal secretion is a secretion formed by a gland, to be poured into the blood or lymph system, while an external secretion is poured out through ducts to the exterior. The thyroid and adrenal glands form internal secretions only, which secretions, poured into the blood and lymph, profoundly affect the nutrition of the body.
The color increases in depth; other secretions are checked; the animal becomes hide-bound, and the milk goes off. Appetite and rumination are suspended; the pulse becomes extremely feeble and frequent, though as in all debilitating, or anæmic, disorders the heart's action is loud and strong, with a decided venous pulse, or apparent regurgitation, in the large veins of the neck.
In addition, we find an inhibition of the functions of every organ and tissue that consumes energy, but does not contribute directly to motor efficiency. The mouth becomes dry; the gastric and pancreatic secretions are lessened or are completely inhibited; peristaltic action stops.
Its condition does not in the least imply a similar one of the stomach, which is a very different structure, covered with a different kind of epithelium, and furnished with entirely different secretions.
And that the pleasurable sensations arising from these secretions may constitute the unnamed pleasure of exigence, which is contrary to what is meant by tedium vitæ, or ennui; and by which we sometimes feel ourselves happy, without being able to ascribe it to any mental cause, as after an agreeable meal, or in the beginning of intoxication.
The popular belief has been that the pearl was formed by secretions of nacre deposited upon a grain of sand or other foreign particle drawn within the oyster through its contact with the sea's bottom. The other Hornell assertion is that the oyster goeth and cometh at its pleasure; that it is mobile and competent to travel miles in a few weeks.
Our libraries are crammed with books written by spiritual hypochondriacs, who inspected all their moral secretions a dozen times a day. They are full of interest, but they should be transferred from the shelf of the theologian to that of the medical man who makes a study of insanity.
But at the same time in those fevers, where the defect of irritation is owing to the defect of the quantity of sensorial power, as well as to the defect of stimulus, another circumstance occurs; which consists in the partial distribution of it, as appears in partial flushings, as of the face or bosom, while the extremities are cold; and in the increase of particular secretions, as of bile, saliva, insensible perspiration, with great heat of the skin, or with partial sweats, or diarrhoea.
The reason for this is that each person has a cultivated immunity to a given toxic state of the intestinal contents, and when from pressure or the irritation caused by a calculus. there is a denudation of the mucosa the infection that takes place has not the power to arouse a systemic resistance' but can cause only a local inflammation; this inflammation may end in ulceration, or it may cause a thickening of the parts and interfere with drainage from mucous or glandular pockets; then the locked up secretions become intensely toxic, and this sets up a new infection much greater then l the first and powerful enough to cause the system to call out its militia to put down the rebellion.
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