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Then he found cases in which, besides bacteria of one definite and constant form, there were others also accumulated within and around the tubular glands, of various size, some short and thick, others very fine; and be soon concluded that he had to do here with a primary invasion of pathogenic bacilli, which, as it were, prepared the tissues for the entrance of the non-pathogenic forms, just as he had observed, in the necrotic, diphtheritic changes in the intestinal mucosa and in typhoid ulcers.
Assuming that laminitis is due to absorption of harmful products from the intestinal tract permitted through the deranged functioning of the organs of digestion, or assuming that it is due to an extension of the inflammation from the mucosa to the sensitive lamina, or that it is a reflex from a sudden chilling of the skin, we have in any of these conditions a disturbed circulation, and aconitin is the first and foremost of circulation "equalizers."
Where the disease had been progressive the intima, the mucosa and submucosa very seldom, however, the serosa were perforated by ulcers; in many cases there were gangraenous patches in the fundus of the stomach and along the intestinal tract.
This allows the blood, which is being sent to the womb to provide nourishment for the ovum if it be impregnated, to pass into the cavity of the womb, then out through the mouth into the vagina, thence to the external parts. This flow is called the menstrual flow. When the flow ceases the mucosa or lining assumes its former state. This process is repeated every month. Bladder 2. Urethra 3.
Thus he found multitudes of bacteria of various kinds, rendering it impossible to distinguish any special forms, and it was not until he had examined two acute and uncomplicated cases, before hæmorrhage had occurred, and where the evacuation had not decomposed, that he found more abundantly the kind of organism which had been seen so richly in the intestinal mucosa.
Fenwick has mentioned an instance of this nature. According to Osler there is a chronic form of dilatation of the colon in which the gut may reach an enormous size. The coats may be hypertrophied without evidence of any special organic change in the mucosa. The most remarkable instance has been reported by Formad.
The reason for this is that each person has a cultivated immunity to a given toxic state of the intestinal contents, and when from pressure or the irritation caused by a calculus. there is a denudation of the mucosa the infection that takes place has not the power to arouse a systemic resistance' but can cause only a local inflammation; this inflammation may end in ulceration, or it may cause a thickening of the parts and interfere with drainage from mucous or glandular pockets; then the locked up secretions become intensely toxic, and this sets up a new infection much greater then l the first and powerful enough to cause the system to call out its militia to put down the rebellion.
The embryo develops and breathes by material transmitted from the mother through the umbilical cord. We encounter here also a very detailed description of a specimen of exfoliated membrana mucosa uteri which our author mistakes for an embryo, but his remarks at least exhibit the most eager curiosity.
The drugs stimulate peristalsis of the small intestine; each wave from the small intestine breaks on the walls of the cecum, for the colon is loaded with fecal accumulations so that the onrushing contents of the small intestine can not be received by the colon; hence the force of the whole peristaltic impact is spent on the cecum, which must endanger the integrity of the mucosa as well as the musculature.
The patient, a harness-maker of forty-seven, was affected generally over the body, but particularly in the face, hands, and feet. The conjunctival, nasal, and aural mucosa were all involved. The skin felt warm, and pressure did not influence the discoloration. The pains complained of were of an intermittent, burning, shooting character, chiefly in the epigastric and left lumbar regions.
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