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Updated: May 17, 2025
Cold hands and feet plague him, cold feet psychically as well as physically, for a chronic and obsessive indecision is one of his most prominent complaints. A fatigability, that goes with a low blood pressure, lowered body temperature and a disturbed ability to utilize sugar for fuel purposes, is another of his chief complaints.
He died of a cancer of the stomach. But before his death there were noted the mental transformations that succeed deficiency of his central endocrine. Apathy, indolence, fatigability, and frilosity were what impressed his associates at St. Helena. The deterioration of his mentality was also exemplified in his literary diversions, the "Siege of Troy" and the "Essay on Suicide."
Also, the thymus has been discovered diseased in certain mysterious progressive muscular wastings. A remarkable fatigability of muscles, which appears after the slightest exertion, is a feature. The feeding of thymus has caused muscle cramps which apparently depends upon an increased excitability of the muscle nerve endings.
Headache and languor and fatigability, dry skin and lack of appetite for food or exertion on one day or for one week, give way on the next day, or for the next week, to an energetic gayety, and sweaty, flushed skin, a prominent appetite for food and every sort of activity.
In spite of the Great Vegetarian's dialectics, it remains to be explained why a certain species of creative ability has been combined with the fatigability, variability and general wretched irritability of every organ and tissue in the body which taught them that they were sensitive souls imprisoned in the flesh.
But without a doubt, most endocrine influences upon the brain, at work every minute and second of its life, are the subtle ones of molecular chemistry and atomic energetics. We know that such mental qualities as irritability and stupidity, fatigability, and the power to recover quickly or slowly from fatigue, sexual potency and impotence, apathy and enthusiasm are endocrine qualities.
In persons so afflicted there appears a fatigability, a sensitiveness to cold, cold hands and feet, which are sometimes mottled bluish-red, a loss of appetite and zest in life, and a mental instability characterized by an indecision, and a tendency to worry, a weepishness upon the slightest provocation.
And like its variations, variations of their tone, development, reactivity, fatigability, and endurance may be traced to corresponding states of overaction, or underaction, and odd combinations of the different hormones. Much remains to be learned about them and the manner of their control.
The adrenal centered will have a high blood pressure and masculinoid traits, the adrenal inferior will have a low blood pressure and suffer from a constant weakness and fatigability. So each form of reaction to the critical ages is individualized according to the predominating glandular influence in the constitution of the woman.
During the voyage, which lasted five years, he was afflicted often by sea-sickness. A ship-mate relates that after spending an hour with the microscope he would say "Old Fellow, I must take the horizontal for it" and lie down. He would stretch out on one side of the table, then resume his labors for a while when he again had to lie down. Already fatigability had to be fed with rest.
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