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Updated: May 17, 2025
Then there is the extraordinary fatigability of the muscles which occurs in the thymus types, who nevertheless have large well-rounded muscles, a paradox of contradiction between anatomy and physiology.
Darwin's case was pretty certainly that. There can be no doubt that Darwin had an abnormal fatigability, a lack of stamina and endurance in mental as well as physical application which plagued him from the late twenties to the sixties.
In short, the thyroid facilitates energy production, the pituitary its consumption. The pituitary appears therefore as the gland of continued effort. Hence fatigability, an inability to maintain effort, is one of the prominent complaints when there is destruction or an insufficiency of it for one reason or another. As such, it contrasts with the glands of emergency effort, known as the adrenals.
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