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Updated: May 8, 2025
A valuable, practical discovery, illustrating the effect of the granulation of one element in a fluid mass, in aiding its separation, has lately been made: when lead containing a small proportion of silver, is constantly stirred whilst cooling, it becomes granulated, and the grains of imperfect crystals of nearly pure lead sink to the bottom, leaving a residue of melted metal much richer in silver; whereas if the mixture be left undisturbed, although kept fluid for a length of time, the two metals show no signs of separating.
These join hands across the gap, the engineer corps and the commissariat department move up promptly to their support in the form of little vein-construction switches, which bud out from the wounded blood-vessels. The clot is transformed into what we term granulation tissue and begins to organize. A few days later this granulation tissue begins to contract and pull the lips of the wound together.
Having bandaged I applied the glycerate, which soon stopped the profuse bleeding, giving her a small bottle of it to apply subsequently. I asked her to report to me in two or three days, and, on reporting, I found a healthy granulation presenting. Its styptic properties are undoubtedly due to tannic acid, as all the tests I have been able to make prove this to be the case.
On removing the packing on the fifth or sixth day, the surface is found to be covered with minute, red, papillary granulations, which are beginning to fill up the cavity. At the edges the epithelium has proliferated and is covering over the newly formed granulation tissue. As lymph and leucocytes escape from the exposed surface there is a certain amount of serous or sero-purulent discharge.
Tattoo marks may disappear during life; the brighter colours, as vermilion, as a rule, more readily than those made with carbon, as Indian ink; after death the colouring-matter may be found in the proximal glands. With regard to scars and their permanence, it will be remembered that scars occasioned by actual loss of substance, or by wounds healed by granulation, never disappear.
The best defined group is that of the granulomata, which includes such important diseases as tuberculosis and syphilis, and in which different types of chronic inflammation are caused by infection with a specific organism, all having the common character, however, that abundant granulation tissue is formed in which cellular changes are more in evidence than changes in the blood vessels, and in which the subsequent degeneration and necrosis of the granulation tissue results in the breaking down and destruction of the tissue in which it is formed.
When a localised portion of tissue, for example, a piece of skin, is so severely crushed or bruised that its blood vessels are occluded and its structure destroyed, it dies, and, if not infected with bacteria, dries up, and the shrivelled brown skin is slowly separated by the growth of granulation tissue beneath and around it.
The changes that ensue resemble in character those in other tissues, and the extent of the destruction varies according to the way in which the tubercle bacillus and the marrow interact upon one another. The granulation tissue may undergo caseation and liquefaction, or may become encapsulated by fibrous tissue "encysted tubercle."
An animal in poor physical condition, or one kept under unfavorable conditions for healing, cannot recover from the injury rapidly or satisfactorily. WOUND HEALING. The following forms of healing commonly occur in wounds: First and second intention; under a scab, and by abnormal granulation.
The relief of tension which follows the bursting of an abscess, the removal of irritation by the escape of pus, and the casting off of bacteria and toxins, allow the tissues once more to assert themselves, and a process of repair sets in. The walls of the abscess fall in; granulation tissue grows into the space and gradually fills it; and later this is replaced by cicatricial tissue.
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