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Updated: May 8, 2025
The whole of the trunk, as high as they can reach, is consequently often quite denuded of its covering, which in the case of almost any other tree would cause its death, but this has no effect on the mowana except to make it throw out a new bark, which is done in the way of granulation.
The commonest form hydrops is that in which the synovial sheath is distended with a viscous fluid, and the fibrinous material on the free surface becomes detached and is moulded into melon-seed bodies by the movement of the tendon. The sheath itself is thickened by the growth of tuberculous granulation tissue. The bodies are smooth and of a dull-white colour, and vary greatly in size and shape.
When the infection becomes active, the contents of the cavity are transformed into a greenish-yellow pus from which the staphylococcus can be isolated, and the cavity is lined by a thin film of granulation tissue which erodes the surrounding bone and so causes the abscess to increase in size.
This granulation formed itself into distinct organs in the molluscæ; while for the snails, which are the next step, the animalized lime, that seemed the sole final cause of the life of the polypi, assumes all the characters of an ulterior purpose. Refined into a horn-like substance, it becomes to the snails the substitute of an organ, and their outward skeleton.
This method of healing is sometimes spoken of as "healing by granulation" although, as we have seen, it is by granulation that all repair takes place. Healing by Union of two Granulating Surfaces. In gaping wounds union is sometimes obtained by bringing the two surfaces into apposition after each has become covered with healthy granulations.
Mechanical and bacterial irritation causes the injured tissue to become swollen and inflamed. In such a wound, excessive and rapid granulation occurs, the new tissue piling up over the cut surfaces and appearing red and uneven. This is termed excessive granulation or "proud flesh." This tissue may refuse to "heal over," or the scar may be large, prominent and painful.
A sinus is lined by granulation tissue, and when it is of long standing the opening may be dragged below the level of the surrounding skin by contraction of the scar tissue around it. As a sinus will persist until the obstacle to closure of the original abscess is removed, it is necessary that this should be sought for.
In small arteries these clots extend as far as the nearest collateral branch, but in the larger trunks their length varies. The permanent occlusion of those portions of the vessel occupied by clot is brought about by the formation of granulation tissue, and its replacement by cicatricial tissue, so that the occluded segment of the vessel is represented by a fibrous cord.
The changes subsequent to the formation of tuberculous granulation tissue are liable to many variations.
The transformation of this temporary granulation tissue into scar tissue is effected by the fibroblasts, which become elongated and spindle-shaped, and produce in and around them a fine fibrillated material which gradually increases in quantity till it replaces the cell protoplasm.
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