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Updated: May 8, 2025
Dead tissue, on the other hand, can do neither of these things; it is only capable of acting as a model, or, at the most, as a scaffolding for such mobile tissue elements as may be derived from, the parent tissue with which the graft is in contact: a portion of sterilised marine sponge, for example, may be observed to become permeated with granulation tissue when it is embedded in the tissues.
When the disease begins in the bone, the marrow is converted into granulation tissue, which eats into the cartilage and separates it from the bone. Following on the destruction of the cartilage, the articular surface of the bone undergoes disintegration, a condition spoken of as caries of the articular surface.
It is, however, only when the proliferative changes have come to predominate that the reparative process is effectively established by the production of healthy granulation tissue. Formation of Granulation Tissue.
Around each colony of actinomyces is a zone of granulation tissue in which suppuration usually occurs, so that the fungus comes to lie in a bath of greenish-yellow pus. As the process spreads these purulent foci become confluent and form abscess cavities. When metastasis takes place, as it occasionally does, the fungus is transmitted by the blood vessels, as in pyæmia. Clinical features.
When the edges of a wound cannot be approximated either because tissue has been lost, for example in excising a tumour or because a drainage tube or gauze packing has been necessary, a greater amount of granulation tissue is required to fill the gap, but the process is essentially the same as in the ideal method of repair.
In superficial bones, such as the sternum, the formation of tuberculous granulation tissue in the deeper layer of the periosteum, and its subsequent caseation and liquefaction, is attended by the insidious development of a doughy swelling, which is not as a rule painful, although tender on pressure.
The actinomyces, which has never been met with outside the body, gives rise in oxen, horses, and other animals to tumour-like masses composed of granulation tissue; and in man to chronic suppurative processes which may result in a condition resembling chronic pyæmia.
The free opening up of the wound is almost immediately followed by a fall in the temperature. The surrounding inflammation subsides, the discharge of pus lessens, and healing takes place by the formation of granulation tissue the so-called "healing by second intention." Wound infection may take place from catgut which has not been efficiently prepared.
The first indication is to exclude bacteria by purifying the damaged part and its surroundings, and applying dry, non-irritating dressings. When these measures are successful, dry gangrene ensues. The raw surface left after the separation of the dead skin may be allowed to heal by granulation, or may be covered by skin-grafts.
This mode of granulation, though tedious, is the only one to be used for so small a quantity, for the sake of experiment. In a large way, gunpowder is granulated by passing the composition through sieves. HADDOCKS. These fish may be had the greater part of the year, but are most in season during the first three months.
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