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Updated: May 16, 2025
So larger animals were taken; and it was finally found that the largest and strongest of our domestic animals, the horse, would, if the diphtheria germs were injected into its blood, make such large amounts of antitoxin that merely by drawing a quart or two of the blood and closing up the vein again enough antitoxin could be got to cure fifty or a hundred children of diphtheria.
It was thought to be a case of diphtheria, and the doctor, to protect his little son, one and one-half years old, against possible infection, administered an injection of antitoxin. Shortly afterward the child developed symptoms of blood-poisoning and died of heart-failure within twenty-four hours.
These effects of the diphtheria toxin are also of interest for a somewhat unexpected reason, since it has been claimed that they are effects of the antitoxin, by those who are opposed to its use.
Wright, of the English Army Medical Staff, has already secured a serum, which has given remarkable results in protecting regiments sent out to South Africa and other infected regions. Chantemesse has imported some six hundred successive cases treated with an antitoxin, whose mortality was only about a third of the ordinary hospital rate, and the future is full of promise.
Morgan took his notebook from his pocket and wrote a few lines in pencil on one of the pages. Then he tore out the leaf and handed it to the Captain. "Send that telegram immediately to my assistant in Boston," he said. "It directs him to send the antitoxin by the early train. If nothing interferes it should be here in time." Captain Hiram took the slip of paper and ran out at the door bareheaded.
It is, of course, first carefully tested on animals when it is manufactured, so that no poisonous product is placed on the market. It is as safe to take salvarsan at the hands of an expert as it is to take ether for an operation or to take antitoxin for diphtheria, and that is saying a good deal.
What is the true moral antitoxin for this class, or at least what is the safety-valve and how and when to pull it, we are now just beginning to learn, but it is a new specialty in the great work of salvage from the wreckage of city life. In London, where these groups are better organised and yet more numerous, war is often waged between them, weapons are used and murder is not so very infrequent.
'Dotted line marks route taken by fatal germ; cross indicates spot where antitoxin attacked it' ha! ha! not much for the yellow journals in that, Craig." "To my mind, Walter, it would be the height of the dramatic far more dramatic than sending a bullet into a man. Any fool can shoot a pistol or cut a throat, but it takes brains to be up-to-date."
In pneumonia we have to let the body largely make its own fight, and simply help it to clear out the poisons formed by the germ, and keep the heart going until the crisis is past. In diphtheria, nowadays, we help the body out promptly by supplying it with antitoxin from an outside source, before it has time to make any for itself. We do the same thing for lockjaw if we are early enough.
In the iris of the eye, the effect of the antitoxin on the system shows as a darkening of the color. In many instances, the formerly blue or light-brown iris assumes an ashy-gray or brownish-gray hue. My secretary who is taking this dictation and who has brown eyes, tells me that her mother informed her that up to her tenth year her eyes had been of a clear blue.
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