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From Ephesus he journeys, complaining of the hot and dusty roads, to Tralles, and from Tralles, one of the cities of his province, to Laodicea, which he reached July 31st, exactly three months after starting . The distance, directly measured, may be reckoned at something less than a thousand miles. He seems to have found the province in a deplorable condition.

An even more striking example than the life and work of Aëtius as evidence for the encouragement and patronage of medicine in early Christian times, is to be found in the career of Alexander of Tralles, whose writings have been the subject of most careful attention in the Renaissance period and in our own, and who must be considered one of the great independent thinkers in medicine.

At Smyrna there is the Stratoniceum, at Tralles, a colonnade on each side of the scaena above the race course, and in other cities which have had careful architects there are colonnades and walks about the theatres.

Prytanes, the son of Hermes, a citizen of yours, came to me when I was at Tralles, and held a court there, and informed me that you used the Jews in a way different from my opinion, and forbade them to celebrate their Sabbaths, and to perform the Sacred rites received from their forefathers, and to manage the fruits of the land, according to their ancient custom; and that he had himself been the promulger of your decree, according as your laws require: I would therefore have you know, that upon hearing the pleadings on both sides, I gave sentence that the Jews should not be prohibited to make use of their own customs."

XLVII. There were many prognostics of the victory, but the most remarkable is that which is reported as having appeared at Tralles. In the temple of Victory there stood a statue of Cæsar, and the ground about it was naturally firm and the surface was also paved with hard stone; from this, they say, there sprung up a palm-tree by the pedestal of the statue.

It was with his father at Tralles that Alexander received his early medical training. The father of a friend and colleague, Cosmas, who later dedicated a book to Alexander, was also his teacher, while he was in his native city. As a young man, Alexander undertook extensive travels, which led him into Italy, Gaul, Spain, and Africa, everywhere gathering medical knowledge and medical experience.

He was followed by Alexander of Tralles, probably a Christian, for his brother was the architect of Santa Sophia, and by Paul of Ægina, with regard to whom we know only what is contained in his medical writings, but whose contemporaries were nearly all Christians.

I have already referred to the late Greeks, Aetius and Alexander of Tralles. The last of the Alexandrians was a remarkable man, Paul of AEgina, a great name in medicine and in surgery, who lived in the early part of the seventh century. He also, like Oribasius, was a great compiler.

Translated into Latin, Syriac, Arabic, and Hebrew, they saturated the intellectual world of the Middle Ages. Commented on by later Greek writers, who were themselves in turn translated into the same list of languages, they were yet again served up under the names of such Greek writers as Oribasius, Paul of Aegina, or Alexander of Tralles.

Other important Byzantine writers were Aetius and Alexander of Tralles, both of whom were strongly under the influence of Galen and Hippocrates. Their materia medica was based largely upon Dioscorides. From Byzantium we have the earliest known complete medical manuscript, dating from the fifth century a work of Dioscorides one of the most beautiful in existence.