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Updated: June 11, 2025
An abnormal process in the anterior gland, whether of oversecretion or of undersecretion, may interfere with the proper functioning of the posterior gland, the secretion of which is tonic not only to the brain cells, but also to the sex cells. Thus, young animals deprived of the pituitary will not, if male, grow spermatozoa, nor ripe ova in the female.
The feeding of pituitary gland in large enough quantities to these unfortunates may do more than ten charity organizations, with the most patrician board of directors complete.
Both of these involutions of the glands of childhood must occur before the normal hypertrophy and development of the sex glands and their secretions can start. Besides, there must be a minimum activity of the thyroid, adrenal and pituitary glands.
"There must be," he says, "some gross change in those parts of the endocritic system, especially apart from the genital glands, which normally produce masculinity potentiality that appears to be concentrated in the suprarenals, the pituitary and probably in the pineal." What, then, do we mean by "male" and "female" in man? Yet an operation proved that the sex glands themselves were male.
Always, in attempting to understand the pituitary, it is necessary to remember that it is tightly packed in the bony cradle, the Turkish Saddle or Sella Turcica. Should some stimulus, local, or in the blood, arouse the gland to growth, a good deal will depend upon whether it has room to grow in, or it will make room by eroding the bone.
One of the glands, the thyroid, for example, will show, by the traces it has left upon the earliest developing features, that it was in control at the very earliest dates of his history, while other signs will disclose the more recent influence of the adrenal or of the pituitary. The combination becomes classifiable as the thyroid-pituitary type, or as the thyroid-adrenal type.
After battles, the trouble became worse so that it interfered with his riding. Constitutional difficulties in urination have been connected definitely with the function of the pituitary.
With space for the formation of a large anterior and posterior pituitary gland, there will be created the long, lean individual, with a tendency to high blood pressure and sexual trends, great mental activity, initiative, irritability and endurance.
They think that when the venous pressure is increased only by large doses of epinephrin, pituitary extract and alcohol, the effect is due to failure of the heart, although it may be due to an increase of carbon dioxid in the blood, in other words, to asphyxia. Arterial hypertension may be divided into stages.
X-ray examination of the sella turcica shows what is called erosion of the bone as it yields to the pressure of the growing gland. The ideal sella turcica for the ideal pituitary type is a large room in which the gland may grow and reach its maximum size and so its maximum function, without needing to exert pressure or destroy and erode bone in front of it, to the side of it or behind it.
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