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Their cells are the most complex, have the most numerous branches and association fibres. They store the fruits of abstract thinking, mathematics, for example. The anterior pituitary is in the closest relation and contact with them. Its secretion is tonic to them.

Men for hundreds of years have been seeking the "fountain of youth." Ponce de Leon when he landed in Florida and saw the beautiful springs and flowers thought he had found it, and so announced to the world. Long ago we learned that the pituitary gland influenced growth and development. For instance if the pituitary gland over-functioned we had Giantism.

That possibly represented pituitary stabilization, and so an abeyance of the ability to vary, necessary for fresh adaptation to a changing environment. Indeed, endocrine instability appears the fundamental condition of the tendency to vary, endocrine stability the opposite. Certain endocrine facts in relation to heredity should be mentioned.

The puerility of these productions, as well as of his conduct, a sulking before his captors, and the decline of his physical energy, once a bottomless well, all point to the same conclusion. The rise and fall of Napoleon followed the rise and fall of his pituitary gland.

Pituitary sufficient and dominant: Large, spare, bony frame Eyes wide apart Broad face Teeth, broad, large, unspaced Square, protruding chin and jaws Large feet and hands Early hair growth on body Thick skin, large sex organs Aggressive, precocious, calculating, self-contained

The secretion or secretions of the pituitary diffuse directly into the fluid bathing the nervous system, supplying beneficent stimulants and aiding in the abstraction of harmful waste.

We know now that if Carol Kennicott's complexion became rotten and her hair fell out, it was because her thyroid was not adequate to the demands of pregnancy, and that if her arches were falling, and her figure acquiring a potato bag dumpiness, it was because her pituitary was insufficient.

In turn the pituitary would become stabilized in the direction of increased secretion, and hand on the component of increased secretion to the sex cells. That component, in conjunction with other factors, would therefore determine the emergence of a definite species character.

The skin was noticed to be very white and delicate as were the hands and arms. Indeed the whole body was slender and effeminate. The pubis much resembled the Mons Veneris in women. The muscles of the chest were small, the shoulders were narrow and the hips wide." In other words, the typical feminization of the body which accompanies pituitary insufficiency was found.

If the pituitary and the thyroid can enlarge to compensate for their defects, they may become the queer brilliants, the eccentric geniuses of the arts and sciences. Should they not, mental deficiency and delinquency are their portion. Epilepsy, then, is sometimes their mode of escape from the terrors of an utterly foreign world.