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Two most important instincts, therefore, which in the complexity of their sublimations have created most of the institutions of society, the maternal and the intellectual, are connected directly with a proper function of the pituitary endocrines.

He has the height, the facial features, the hands, and the sort of mentality that run together in his endocrine make-up. He also has the headaches. It is quite probable that feeding him pituitary gland extract in the proper dosage would relieve him of his headaches.

Not until 1908 was the problem solved by Paulesco of Bucharest, who devised a way of reaching it by trepanning the skull. He was thus able to prove beyond a doubt that the pituitary gland was essential to life, and that without it no animal could continue to live for any length of time.

The pituitary, too, begins to retrogress after the period of maturity. And an early retrogression means a short maturity. In women, the onset of an obesity, and coincidently, of a lazy and dull morale, coincides with this declension of the pituitary powers. All the glands of internal secretion, in fact, shrink and shrivel as old age advances.

Ovary and adrenal medulla and posterior pituitary and thyroid predominance constitute the feminine formula. Testis and adrenal cortex and anterior pituitary predominance comprise the masculine endocrine directorate. As in so many other aspects, the facts about the various influences exerted by the endocrine glands upon the reproductive system are complicated and disjointed.

The record of his physique and physiognomy, documentary and that left in portraits and photographs. He was tall and thin and his frame was naturally strong and large. Face was ruddy, and his grey eyes looked out from under deep overhanging brows and bushy eyebrows. The ears were large and prominent, the hair straight, the nose broad and well developed. All these are distinctive pituitary traits.

There are, in the corporation-organism, different departments and bureaus, subdivisions of function, which constitute the smaller corporations within the larger corporation. These subsidiary companies have their own glands of internal secretion as their directors. Thus, the growth of the brain is presided over by the adrenal cortex, the thyroid, the thymus and the pituitary.

Individuals oversized or undersized either belong to the pituitary type, or if hyphenated, have the pituitary as one of the dominants in their composition. The necessities of child-bearing determine a greater angle between trunk and lower extremities in the female. Underactivity of the pituitary, for instance, will prevent the development of the normal angle.

Their size and consistence are variable sometimes soft, tearing with the greatest facility, and bleeding at the slightest touch; at other times, solid and covered with pituitary membrane. They are generally the result of ulcerations, wounds, fractures, perforations of the turbinated bones, sinuses,&c.

There are losses of balance, so that when one gland ceases secreting, another will simultaneously or soon after. Normal secretion, oversecretion or undersecretion are thus adjusted, but leave a train of after effects. So with loss or insufficiency of the thyroid, there may be pituitary overgrowth, because the pituitary may act as vicar for the thyroid.