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These are homogeneous or concentrically laminated masses of fibrin, sometimes resembling rice grains, melon seeds, or adhesive wafers, sometimes quite irregular in shape. Usually they are present in large numbers, but sometimes there is only one, and it may attain considerable dimensions.
Clinically, loose bodies composed of fibrin constitute an unimportant addition to the features of the disease with which they are associated. They never give rise to the classical symptoms associated with impaction of a loose body between the articular surfaces.
Place in each tube an equal amount of well-washed fibrin, plug the tubes with absorbent cotton, and place all in a water-bath at about 100 degrees F. Experiment 73. Examine from time to time the three test tubes in the preceding experiment.
They may be briefly classified as: 1. Those that cause a partial or complete closure of the lymph spaces and Schlemm's canal by cicatrical contraction, as in sclero-keratitis. Those that cause obstruction to the lymph spaces at the filtration angle by the deposition of fibrin or cellular elements, as in iritis, hemorrhage into the anterior chamber, etc.
It is supposed to result from the breaking down of the white corpuscles, and perhaps also from the blood platelets, when the blood is exposed to unnatural conditions. The formation of the ferment leads in turn to the changing of the fibrinogen into fibrin. Another substance which is necessary to the process of coagulation is the element calcium.
The tongue, for instance, is, like all other parts of the animal frame, composed of gelatine, fibrin, and other products of the chemistry of digestion, but from no knowledge of the properties of those substances could we ever predict that it could taste, unless gelatine or fibrin could themselves taste; for no elementary fact can be in the conclusion, which was not first in the premisses.
This sloughing of the globule would be the same as if exhibited on any other part of the organization, for the fibrin is identical with muscle, as albumen is identical with the white of an egg; and since congestion is the forerunner of gangrene at the extremities, or on the surface, so fever and quick pulsation are the forerunners of congestion of the blood.
The slightest movement causes pain, and the part is sensitive to touch. The skin is hot and tense, and in the case of the elbow may be red and fiery as in erysipelas. The deposit of fibrin on the synovial membrane and on the articular surfaces may lead to the formation of adhesions, sometimes in the form of isolated bands, sometimes in the form of a close fibrous union between the bones.
Obtain a pint of fresh blood; put it into a bowl, and whip it briskly for five minutes, with a bunch of dry twigs. Fine white threads of fibrin collect on the twigs, the blood remaining fluid. This is "whipped" or defibrinated blood, which has lost the power of coagulating spontaneously. General Plan of Circulation. All the tissues of the body depend upon the blood for their nourishment.
This softening and some swelling of the lower layers of the endocardium allow the pushing up of these extravasated blood cells which, being covered with fibrin, makes the little vegetations above described; and as just stated, the fibrin may form a more or less permanent cap.
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