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Updated: May 9, 2025
But as I have never known fatal effects arise from the cow-pox, even when impressed in the most unfavourable manner, producing extensive inflammations and suppurations on the hands; and as it clearly appears that this disease leaves the constitution in a state of perfect security from the infection of the smallpox, may we not infer that a mode of inoculation may be introduced preferable to that at present adopted, especially among those families which, from previous circumstances, we may judge to be predisposed to have the disease unfavourably?
There is something frightful in the disposition of certain ophidians, as the whipsnake, which darts at the eyes of cattle without any apparent provocation or other motive. It is natural enough that the evil principle should have been represented in the form of a serpent, but it is strange to think of introducing it into a human being like cow-pox by vaccination.
This excited my curiosity, and when I visited Gloucestershire I was very inquisitive concerning the subject, and from the information I have since received, both from your publication and from conversation with medical men of the greatest accuracy in their observations, I am fully convinced that what the men supposed to be cow-pox was actually so, and I can safely affirm that they effectually resisted the smallpox."
He has since informed me "that he inoculated children at the breast, whose mothers had not gone through either the smallpox or the cow-pox; that he had inoculated mothers whose sucking infants had never undergone either of these diseases; that the effluvia from the inoculated pustules, in either case, had been inhaled from day to day during the whole progress of their maturation, and that there was not the least perceptible effect from these exposures."
Henry Jenner, whose report to me is as follows: "I have inoculated Pead and Barge, two of the boys whom you lately infected with the cow-pox. On the second day the incisions were inflamed and there was a pale inflammatory stain around them. On the third day these appearances were still increasing and their arms itched considerably.
CASE XVI. Sarah Nelmes, a dairymaid at a farmer's near this place, was infected with the cow-pox from her master's cows in May, 1796. She received the infection on a part of her hand which had been previously in a slight degree injured by a scratch from a thorn. A large pustulous sore and the usual symptoms accompanying the disease were produced in consequence.
Needless to say, I refer to Jenner's discovery of the method of preventing smallpox by inoculation with the virus of cow-pox. It detracts nothing from the merit of this discovery to say that the preventive power of accidental inoculation had long been rumored among the peasantry of England. Such vague, unavailing half-knowledge is often the forerunner of fruitful discovery.
The disease went through its course without any deviation from its usual habits; and, notwithstanding this, the cow-pox virus excited its common appearances, both on the arm and on the constitution, without any febrile interruption; on the sixth day there was a vesicle. 8th: Pain in the axilla, chilly, and affected with headache. 9th: Nearly well.
The inquiry I have instituted into the nature of the cow-pox will probably promote its more perfect investigation. The inquiry of Dr.
As universal inoculation was manifestly impracticable, any half-way measure was decidedly disadvantageous, and it was not until vaccination from cow-pox was instituted that the first decided check on the ravages of small-pox was made. Vaccination was almost solely due to the persistent efforts of Dr. Edward Jenner, a pupil of the celebrated John Hunter, born May 17, 1749.
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