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No one has shown satisfactorily the process by which the blood-corpuscles are formed out of the lymph-corpuscles, nor what becomes of them. These two questions are like those famous household puzzles, Where do the flies come from? and, Where do the pins go to?

But they all agree in certain characters; all take their food and oxygen and carry on excretory processes by osmosis, i.e., through the body-wall; all are capable of some kind of locomotion, some have one or more flagella, others move by a pseudopod movement. Some are capable of moving from cell to cell in the body as do the white blood-corpuscles.

Phallin is a toxalbumin which destroys the red blood-corpuscles, causing the serum to become red in colour and the urine blood-stained. Fibrin is liberated, and thromboses occur, especially in the liver. The symptoms may be mistaken for phosphorus-poisoning or acute yellow atrophy of the liver. Muscarine affects the nervous system chiefly.

Another most important class in the cell-community is the great group of the blood-corpuscles, which in some respects appear to maintain their independence and freedom to a greater degree than almost any other class which can be found in the body.

Grancher directs the anti-rabic department and allied fields. Metchnikoff, a Russian by birth and Parisian by adoption, is famous as the author of the theory that the white blood-corpuscles of the blood are the efficient agents in combating bacteria.

They are only the one two-thousandth of an inch in diameter, and are known as the white or colourless corpuscles of the blood. They are far less numerous than the red blood-corpuscles, which are the agents for carrying oxygen, but there are eight thousand million of them in a large spoonful of blood.

"There was a frothy mucus in the bronchial tubes. The blood was liquid, dark, and didn't clot. The fact of the matter is that the autopsical research revealed absolutely nothing but a general disorganisation of the blood-corpuscles, a most peculiar thing, but one the significance of which none of us here can fathom.

The tubes take some part in the process of menstruation; their mucous membrane is swollen, the epithelium is shed in places, and they are filled with a thin bloody fiuid, containing blood-corpuscles and cast-off epithelium cells. The menstrual wave continues from puberty to the menopause; it is a nervous phenomenon.

As the phenomena of chills and fever are most strikingly exhibited in malaria, let us study the course of events in that disease. It is known that the malarial parasite develops in the red blood-corpuscles, and that the chills and fever appear when the cycle of parasitic development is complete and the adults are ready to escape from the corpuscles of the blood plasma.

Thus in a very short time many generations of this parasite occur and thousands or hundreds of thousands of the red-blood corpuscles are destroyed, leaving the patient weak and anemic. It will be seen, too, that the recurrence of the chills and fevers is simultaneous with the escaping of the parasites from the blood-corpuscles, together with the waste products of their metabolism.