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Updated: May 16, 2025
Ladenburg has also formed a series of artificial alkaloids, called tropeines, by uniting the base tropine with different organic acids, as in the case of the compound of mandelic acid and tropine, known as homatropine, an alkaloid of action similar to atropine, but possessing some decided advantages in its use.
=Calabar Bean or Physostigma.= The bean of Physostigma venenosum contains the alkaloid physostigmine or eserine, with the antagonistic alkaloid calabarine. Symptoms. Vomiting, giddiness, irregular cardiac action, contraction of the pupils, paralysis of lower extremities, and death from asphyxia. Treatment. Emetics; hypodermic injection of 1/50 grain sulphate of atropine, repeated if necessary.
All parts of the plant are poisonous; the seeds, which are contained in pods, are often eaten by children. Contains the alkaloid cytisine, which is also contained in arnica. It has a bitter taste, and is powerfully toxic. Symptoms are purging, vomiting, restlessness, followed by drowsiness, insensibility, and convulsive twitchings. Death due to respiratory paralysis.
Tried rhythmic traction of the tongue, artificial respiration, stimulants, chest and heart massage everything, but it was no use:" "Have you any idea what caused his death?" asked Craig as he hastily adjusted his apparatus to an electric light socket a rheostat, an induction-coil of peculiar shape, and an "interrupter." "Poison of some kind an alkaloid.
"Aconitine?" questioned Penfield, and the reporters, scenting the sensational, leaned forward eagerly so as not to miss the deputy coroner's answer. "Aconitine, an active poison," he explained. "It is the alkaloid of aconite, and generally fatal in its results."
Both its lack of uniformity and its difficulty of exhibition may be nullified by using the active principle. It has been one of the opprobria medicina that in a drug known to possess such wonderful properties so little advance has been made toward the isolation of the alkaloid or resinoid on which it depends for its potency.
Brucine is a tertiary diamine, that is, formed by substitution in a double ammonia molecule. When distilled with potassium hydrate it yields quinoline, lutidine, and two isomeric collidines. The alkaloid atropine has been quite thoroughly studied with results of great interest.
"Holmes is a little too scientific for my tastes it approaches to cold-bloodedness. I could imagine his giving a friend a little pinch of the latest vegetable alkaloid, not out of malevolence, you understand, but simply out of a spirit of inquiry in order to have an accurate idea of the effects. To do him justice, I think that he would take it himself with the same readiness.
It was the first alkaloid to be synthesised. Here is a sample, this colourless, oily fluid. No doubt you have noticed the mousey odour in this room. As little as one part of conine to fifty thousand of water gives off that odour it is characteristic. "I have proceeded with extraordinary caution in my investigation of this case," he went on.
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