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Updated: June 17, 2025
Through the tiny, solitary veins of the glands, an infinitesimal quantity of the reserve adrenalin responds. And with what an effect! The blood, that primary medium of life, the precious fluid that is everything, must all, or nearly all, be sent to the firing line, the battle trenches, the brain and muscles, now or never.
The relation between the adrenal and the skin dates way back in the evolutionary scale, for adrenalin has been isolated directly from pigment deposits in the epidermis of frogs. Skin pigment bears a direct relation to the reaction of the organism to light, especially the ultraviolet rays, to the radiation of heat, and hence to the fundamental productions and consumptions of energy by the cells.
Adrenalin, that weapon of a gland tracing its ancestry back to the begetter of the brain itself, for brain and adrenal gland both have evolved from the small nerve ganglia of the invertebrates, would have backed up to the hilt his argument, which he had to elaborate on the indirect grounds of analogy and induction.
For example, the output of adrenalin is increased, and, as a consequence, arteriosclerosis and cardiovascular disease may occur in persons who have been subjected to prolonged emotional strain, since it has been proved that the prolonged administration of adrenalin will cause these conditions. We have stated that the emotions cause increased output of glycogen.
For some days after the pituitrin was stopped its influence seemed to persist as the pressure kept high while the mental condition was low. One of her longest spells of continuous mental depression which lasted for twenty-seven days, occurred while her pressure was high under the influence of adrenalin.
As adrenalin increases blood-pressure, so thyroid secretion increases brain activity, and increased brain activity in turn causes an increased activation of the motor mechanism as a whole. We know that a deficiency or lack of thyroid secretion will inhibit sexual emotion and conception, will produce stupidity and inertia; will diminish vitality.
Unfortunately, the thyroid cannot be studied to advantage either functionally or histologically, for there is as yet no available test for thyroid secretion in the blood as there is for adrenalin, and thyroid activity is not attended by striking histologic changes.
She thought about how little of a human's mercurial life was grounded in the present moment: an athlete was in the rush of his adrenalin, a conversation consisted of past events and future expectations, and a current event was impinged by pertinent hunches exhumed from the subconscious in daydreams.
When adrenalin is injected under the skin in sufficient quantity, it will produce paleness, trembling, erection of the hair, twitching of the limbs, quick or gasping breathing, twitching of the lips all the classic manifestations of fear. These are the immediate effects of fear because they are the immediate effects of excess adrenalin in the blood upon the vegetative viscera and the muscles.
Further striking testimony in favor of the hypothesis that the production of acidity by inhalation anesthetics is the method by which anesthesia itself is produced is found in the fact that although lethal doses of acid cause muscular paralysis, yet this paralysis may be mitigated by adrenalin which is alkaline.
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