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Updated: June 17, 2025
More in harmony with the clinical experiences here is the fact according to Biedl "that the adrenalin affects the intracranial and the pulmonary vessels only slightly if at all." We presume that what is true of adrenalin in this respect will be true of all drugs which increase blood pressure.
I have never been able to persuade myself that, except as an adjuvant to operative work, there was any real therapeutic value in the instillation of adrenalin. A word in regard to the effect of general narcosis on intra-ocular tension. Thus, Neuschuler has observed that narcosis causes an elevation of the intra-ocular tension of from 2 to 6 degrees as measured with Fick's tonometer.
We may therefore tentatively assume that the fever which marks the onset and frequently the course of these benign stupors is the result of a failure of the heat loss function, this being due to an imbalance in the involuntary nervous system that is occasioned, in turn, by insufficient circulating adrenalin, and the final cause for the poor suprarenal function is to be traced to the most consistent symptom of the stupor, namely, apathy.
Fueled on adrenalin and hunger, he finds himself walking behind her in the rain. He imagines himself catching up and offering his umbrella to her but she has one of her own and so he timidly tracks her from a distance. He imagines her dropping the keys to her car but the fates also do not allow him this prop.
Moreover, the process of liberation of sugar from glycogen itself in the liver, upon demand, is today set down to the action of an internal secretion, adrenalin. Claude Bernard's conception, like a novelist's characters, has turned upon its creator, taken on a life of its own, and evolved into something he never intended.
The pure adrenalin was isolated, capable of evoking all the reactions of the impure adrenal extract mixtures. The final triumph was the preparation of it artificially in the laboratory, its synthesis. When a substance can be synthesized in the chemist's laboratory, it means that its composition has become thoroughly understood.
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