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Updated: June 2, 2025
Quinin has not been shown to be of value, and salicylic acid is rarely of value unless the cause is rheumatism. Alcohol has been used in large doses, as it has been so frequently used in all septic processes. If the patient is unable to take nourishment in any amount, small doses of alcohol may be of benefit. It is probably of no other value.
The benzol was bought up by a company specially formed for the purpose, who sent it to a chemical works under German management to be manufactured into salicylic preparations. These products were sold for the most part for the American market, and also, with the approval of the Ministry for War, exported to neutral countries.
As it acts at times almost as a specific in rheumatism, it would seem that it should be of value in the endocarditis caused by rheumatism. On the other hand, the endocarditis occurs during the second or third week of acute rheumatism, after the blood has been thoroughly saturated with salicylic acid.
Until we have some positive knowledge to the contrary, alkalies should be freely administered during endocarditis, especially during rheumatic endocarditis. Potassium citrate in 2 gm. This may be given with the salicylic acid treatment, and also when the salicylic acid has been stopped.
The author has endeavored to ascertain what agents are able to destroy the spores of bacilli, how they behave toward the microphytes most easily destroyed, such as the moulds, ferments, and micrococci, and if they suffice at least to arrest the development of these organisms in liquids favorable to their multiplication. His results with phenol, thymol, and salicylic acid have been unfavorable.
Benicke reports having given salicylic acid just before birth in 25 cases, and in each case finding it in the urine of the child shortly after birth. At a discussion held in New York some years ago as to the real effect on the fetus of giving narcotics to the mother, Dr. Gaillard Thomas was almost alone in advocating that the effect was quite visible.
Gusserow of Strasbourg tested for iodin, chloroform, and salicylic acid in the blood and secretions of the fetus after maternal administration just before death. In 14 cases in which iodin had been administered, he examined the fetal urine of 11 cases; in 5, iodin was present, and in the others, absent. He made some similar experiments on the lower animals.
Not only the fever process, but also the salicylic acid tends to prevent the healthy normal growth of red corpuscles. and such patients suffering from rheumatism are often seriously anemic after the aente inflammation has ceased. As so many times repeated, real pain must be stopped, and morphin, either by the mouth or hypodermically, should be used to the point of stopping such pain.
After soaking in hot water, the overgrown horny layer is pared away, and the part painted daily with a saturated solution of salicylic acid in flexile collodion. [Illustration: FIG.
Salicylic acid in medicinal doses frequently causes untoward symptoms, such as dizziness, transient delirium, diminution of vision, headache, and profuse perspiration; petechial eruptions and intense gastric symptoms have also been noticed.
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