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Updated: June 29, 2025
In addition, it may be as well to remember that death sometimes occurs suddenly in exophthalmic goitre, hypertrophy of the thymus, and in Addison's disease. In some cases of sudden death nothing has been found post mortem, even when the autopsy has been made by skilled observers, and the brain and cord have been submitted to microscopical examination. Cadaveric appearance; ashy white colour.
It was as though some diabolical force had taken possession of his brain, and he fought it off, but was unable to conquer. Kennedy followed the staring glance of Whitney's eyes, which seemed almost to pop out of his head, as though he were suffering from the disease exophthalmic goitre. I looked also.
Hence it may well follow that the disappointed maiden who is intensely integrated for a youth will, at every thought of him, be subjected by phylogenetic association to a specific stimulation analogous to that which attended the ancestral consummation. Moreover, a happy marriage has many times been followed by a cure of the exophthalmic goiter which appeared in the wake of such an experience.
Even if he had accomplished nothing else he had struck a note which had caused the Athertons to forget their former superciliousness. "If there is an oversupply of thyroid hormones," continued Craig, "that excess will produce many changes, for instance a condition very much like exophthalmic goiter.
Mental disease began after father's death. Constant self condemnation. Suicidal. Exophthalmic goiter. Autopsy: Thyroid glandular hyperplasia. Mitral sclerosis. Aortic sclerosis with ulceration. Chronic endocarditis. Chronic diffuse nephritis. Scars of both apices of lungs, with small abscess of left apex. Emaciation. Brain weight 1050 grams.
If the brain cannot endure the strain, then neurasthenia, nerve exhaustion, or even insanity follows. If the thyroid cannot endure the strain, it undergoes hyperplasia, which in turn may result in a colloid goiter or in exophthalmic goiter. If the adrenals cannot endure the strain, cardiovascular disease may develop.
In excess they produce such diseases as exophthalmic goiter, and goiter is concerned with the enlargement of the glands and surrounding tissues beyond anything like natural size. Then, too, a defect in the glands causes the disease known as myxedema in adults and cretinism in children. Most of all, the gland seems to tell on the germ plasm of the body, especially in women."
A remarkable study of the modification of laughter and crying by disease is found in that most interesting of diseases exophthalmic goiter. In this disease there is a low threshold to all stimuli. That the very motor mechanism of which we have been speaking is involved, is shown by an enormous increase in its activity.
The tachycardia of a developed exophthalmic goiter is difficult to inhibit. Digitalis is of no avail, and no other single medicinal treatment is of any great value. The tachycardia will improve as the disease improves. On the other hand, nothing is snore serious for this patient than her rapid heart, and if it cannot be soon slowed, operative interference is absolutely necessary.
Goiter is the most common disorder of the thyroid gland; though not very serious in minor cases, it is capable of becoming very dangerous, assuming such malignant forms as exophthalmic goiter, which is marked by palpitation of the heart, nervous symptoms and protrusion of the eyes.
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