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Updated: June 29, 2025
Eight hours of continuous sleep restored all the cells except those that had been completely exhausted. This will explain the permanent ill effect of long-continued insomnia; that is, long-continued insomnia permanently destroys a part of the brain-cells just as do too great physical exertion, certain drugs, emotional strain, exophthalmic goiter, and hemorrhage.
This is undoubtedly the reason why a severe case of exophthalmic goiter sustains a permanent loss of brain power. Insomnia. The brains of rabbits which had been kept awake for one hundred hours showed precisely the same changes as those shown in physical fatigue, strychnin poisoning, and exhaustion from emotional stimulation.
The function of the thyroid in the kinetic chain is best evidenced, however, by its role in the production of fever. Fever results from the administration of thyroid extract alone in large doses. In the hyperactivity of the thyroid in exophthalmic goiter one sees a marked tendency to fever, in severe cases there is daily fever.
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