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Lipomas are also met with growing from the adipose connective tissue between or in the substance of muscles, and, when situated beneath the deep fascia, such as the fascia lata of the thigh, the characteristic signs are obscured and a differential diagnosis is difficult. It may be differentiated from a cold abscess by puncture with an exploring needle.

This is surrounded by a sheath of connective tissue, at first merely membranous, later becoming cartilaginous or gristly. Pieces of cartilage extend upward over the spinal marrow, and downward around the great aortic artery, forming the neural and hæmal arches.

Muscles and connective tissue pass from the thyroid to the cricoid cartilage at all places, save one on each side, where the downward projections of the thyroid form hinge joints with the cricoid. These joints permit of motion of either cartilage upon the other. At the summit of the cricoid cartilage, on each side, is a small piece of triangular shape, called the arytenoid cartilage.

The fusion of the cartilaginous surfaces is preceded by the spreading of a vascular connective tissue, derived from the synovial membrane, over the articular cartilage. It may follow upon fibrous or cartilaginous ankylosis, or may result from the fusion of two articular surfaces which have lost their cartilage and become covered with granulations.

When there is much connective tissue formed in relation to the synovial membrane, the joint is swollen, and as the muscles waste above and below, the swelling is spindle-shaped. Subacute exacerbations occur from time to time, with fever and aggravation of the local symptoms and implication of other joints.

The sclerotic coat covers the greater portion of the larger spherical segment and is recognized in front as "the white of the eye." It is composed mainly of fibrous connective tissue and is dense, opaque, and tough. It preserves the form of the eyeball and protects the portions within.

Between and beneath the corpora cavernosa lies the corpus spongiosum which consists principally of the urethra. Around these three cylindrical bodies there is a sheath of loose connective tissue, outside of which is the skin.

Each muscle has its own set of blood-vessels, lymphatics, and nerves. It is the blood that gives the red color to the flesh. Blood-vessels and nerves on their way to other parts of the body, do not pass through the muscles, but between them. Each muscle is enveloped in its own sheath of connective tissue, known as the fascia.

The edges of the diaphragm are firmly attached to the walls of the trunk, and the center is supported by the pericardium and the pleura. The outer margin is muscular, but the central portion consists of a strong sheet of connective tissue. By the contraction of its muscles the diaphragm is pulled down, thereby increasing the thoracic cavity.

In the smaller arteries there is more or less uniform thickening of the tunica intima from proliferation of the endothelium and increase in the connective tissue in the elastic lamina a form of obliterative endarteritis. The narrowing of the vessels may be sufficient to determine gangrene in the extremities.