Soto sent several messages to the cacique requesting peace, but he constantly refused to be seen or to send any answer. Leaving Anilco, and crossing the river on which it stood without opposition, the Spaniards marched through an extensive unpeopled wilderness overgrown with wood, and came into the province of Guachacoya.

The general gave them all favourable answers, yet kept himself carefully on his guard. Quiqualtanqui invited Anilco to join in the confederacy, instead of which he gave notice of it to the Spaniards. It was not known how Guachacoya stood affected on this occasion, but he was suspected of having hostile intentions, as he made no communication of the conspiracy.

The cacique of Guachacoya came likewise to wait upon the Spanish general, with a great present, to confirm the former friendship, and though he saw the lieutenant of his enemy among the Spaniards, he took no notice of the circumstance.

Accordingly, they set out on the 5th of July 1542, and marched above 100 leagues to the westwards, through a barren and desert country . On leaving Guachacoya they were joined by an Indian youth of about sixteen years of age, whom they did not observe till the fourth day of their march. Suspecting him of being a spy, Alvarado asked him who he was and what was his object in following them.

Being taken by surprise, as he had received no intelligence of the approach of the Spaniards in consequence of being at war with Anilco, the cacique of Guachacoya saw no likelihood of being able to defend his town, and made therefore a precipitate retreat across the river with his people in canoes and floats, carrying off as many of their effects as they could.

Of the same materials the Spaniards made all kinds of cordage for their brigantines, from the smallest ropes up to cables; and in every thing the cacique Anilco, to whom they had formerly done so much injury, assisted the Spaniards to the utmost of his power, while Guachacoya was exceedingly dissatisfied at seeing the intimacy between them.

Being of opinion that they had declined too much from, the direction of Guachacoya, to which place they now proposed returning, the Spaniards now directed their course eastwards, still inclining somewhat towards the north, so that in this way they crossed the direction they had formerly gone in their march from Auche to the country of the cow-herds, yet without perceiving it.

On midsummer day 1543 the brigantines were launched into the great river, and on St Peters day, the 29th of that month, every thing being in readiness, the brigantines and canoes having defences made of boards and skins to fend off the arrows, they took leave of the friendly caciques, Anilco and Guachacoya, and set sail down the great river.

The Spaniards and their allies now returned to Guachacoya, where Soto gave orders for cutting down and hewing timber with which to build the brigantines, and to prepare iron work for their construction; designing when the vessels were finished to cross the river into a province named Quiqualtangui, which was very fertile and populous, the cacique of which had a town of five hundred houses, but who could never be induced to listen to proposals of peace from the Spaniards: On the contrary, he had sworn by the sun and moon, that he would give battle to these vagabond robbers, and would hang up their quarters on trees.

This province, called Aminoya, lay seventeen leagues farther up the river than Guachacoya, to which they had endeavoured to direct their course on returning from the province of Los Vaqueros. Being somewhat recovered towards the end of January 1543, they set to work to cut down and prepare timber for building their brigantines.