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Updated: May 5, 2025
Several varieties of whitlow are recognised, but while it is convenient to describe them separately, it is to be clearly understood that clinically they merge one into another, and it is not always possible to determine in which connective-tissue plane a given infection has originated. Initial Stage.
This is true not only of the circumscribed gumma, but of the condition known as gummatous infiltration or syphilitic cirrhosis, in which the granulation tissue is diffused throughout the connective-tissue framework of such organs as the tongue or liver. Both the gummatous lesions and the fibrosis of tertiary syphilis are directly excited by the spirochætes.
The lateral cartilages are attached to the posterior angles of the pedal bone. They are flattened from side to side, and the portion that projects above the coronary cushion may be felt by pressing on the skin that covers it. The plantar cushion is a wedge-shaped piece of tissue formed by interlacing connective-tissue fibres and fat. It is limited on each side by the lateral cartilages.
It may be months or even years before the lipping and other hypertrophic changes in the ends of the bones are recognisable, and before the joint assumes the deformed features which the name of the disease suggests. The capsular ligament, except in hydrops, is the seat of connective-tissue overgrowth, and tends to become contracted and rigid.
#Formation of an Abscess.# When pyogenic bacteria are introduced into the tissue there ensues an inflammatory reaction, which is characterised by dilatation of the blood vessels, exudation of large numbers of leucocytes, and proliferation of connective-tissue cells.
A tumour of bone may grow from the cellular elements of the periosteum, the marrow, or the epiphysial cartilage. Primary tumours are of the connective-tissue type, and are usually solitary, although certain forms, such as the chondroma, may be multiple from the outset. Periosteal tumours are at first situated on one side of the bone, but as they grow they tend to surround it completely.
The cells are called connective-tissue corpuscles, cartilage cells, and bone corpuscles, according to the tissues in which they occur. The fibers are the white fibrous and the yellow elastic tissues. The following varieties are usually described: 20. White Fibrous Tissue. This tissue consists of bundles of very delicate fibrils bound together by a small amount of cement substance.
The fat is arranged in lobules separated by connective-tissue septa, which are continuous with the capsule surrounding the tumour and with the overlying skin, which becomes dimpled or puckered when an attempt is made to pinch it up. As the fat is almost fluid at the body temperature, fluctuation can usually be detected.
Peuch found that in one case the ovaries were of normal size three years after the establishment of the menopause. Kiwisch describes the structural change in this gland as consisting, on the one hand, of an increase of the connective-tissue stroma; and, on the other hand, the Graafian vesicles themselves undergo retrograde change.
The introduction of a colony of micro-organisms is quickly followed by an accumulation of wandering cells, and proliferation of connective-tissue cells in the tissues at the site of infection.
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