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The pus therefore tends to burrow along the line of the blood vessels and in the connective-tissue septa, till it either finds a weak spot or causes a portion of fascia to undergo necrosis and so reaches the surface.
The pure myxoma is extremely rare, and clinically resembles the lipoma. Myxomatous tissue is, however, frequently found in other connective-tissue tumours as a result of degeneration, for example, in cartilaginous tumours and in sarcomas. Myxomatous tissue is also a prominent constituent of the "innocent parotid tumour."
When deeply situated, the blood tends to spread along the lines of least resistance, partly under the influence of gravity, passing under fasciæ, between muscles, along the sheaths of vessels, or in connective-tissue spaces, so that it may only reach the surface after some time, and at a considerable distance from the seat of injury.
It is possible for a metaplastic transformation of connective-tissue cells into cartilage cells to take place, the characteristic hyaline matrix being secreted by the new cells. This is sometimes observed as an intermediary stage in the healing of fractures, especially in young bones.
The internal clot plays the most important part in the process; it becomes invaded by leucocytes and proliferating endothelial and connective-tissue cells, and new blood vessels permeate the mass, which is thus converted into granulation tissue. This is ultimately replaced by fibrous tissue, which permanently occludes the end of the vessel.
#Varieties of Tumours.# In the following description, tumours are classified on an anatomical basis, taking in order first the connective-tissue group and subsequently those that originate in epithelium. #Lipoma.# A lipoma is composed of fat resembling that normally present in the body.
Sometimes the blood persists as a collection of fluid with a newly formed connective-tissue capsule, constituting a hæmatoma or blood cyst, more often met with in the scalp than in other parts. The impairment of the blood supply of the skin may lead to the formation of blisters, or to necrosis.
#Traumatic Neuritis.# This consists in an overgrowth of the connective-tissue framework of a nerve, which causes irritation and pressure upon the nerve fibres, sometimes resulting in their degeneration.
The bone is spongy in character, and its development takes place along similar lines to those observed in ossification from the periosteum. #Tumours of Muscle.# With the exception of congenital varieties, such as the rhabdomyoma, tumours of muscle grow from the connective-tissue framework and not from the muscle fibres.
It is believed that this functional heart trouble is caused by the increased connective-tissue fibers of the sexual organs acting in some unknown way on the terminal fibers of the sympathetic; and it is not infrequently due to the formation of scar tissue at the seat of a cervical laceration, and has often been promptly and permanently relieved by removing the cicatricial tissue and suturing the wound.
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